Characterization of the Ubiquitin-Protein Ligase E6-AP by RNA Interference [PDF]
, 2006 The cellular ubiquitin-protein ligase E6-AP was initially identified as a protein that interacts with the E6 oncoprotein of Human papillomaviruses (HPVs) associated with cervical carcinomas.
D'silva, Michael Aloysius
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Dysfunction of the ubiquitin ligase E3A Ube3A/E6-AP contributes to synaptic pathology in Alzheimer's disease. [PDF]
Commun Biol, 2019 AbstractSynaptic dysfunction and synapse loss are prominent features in Alzheimer’s disease. Members of the Rho-family of guanosine triphosphatases, specifically RhoA, and the synaptic protein Arc are implicated in these pathogenic processes. They share a common regulatory molecule, the E3 ligase Ube3A/E6-AP.
Olabarria M +6 more
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Growth Suppression Induced by Downregulation of E6-AP Expression in Human Papillomavirus-Positive Cancer Cell Lines Depends on p53 [PDF]
Journal of Virology, 2005 The ubiquitin-protein ligase E6-AP is utilized by the E6 oncoprotein of human papillomaviruses (HPVs) associated with cervical cancer to target the tumor suppressor p53 for degradation.
Butz, Karin +5 more
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SUMOylation regulates the homologous to E6-AP carboxyl terminus (HECT) ubiquitin ligase Rsp5p. [PDF]
J Biol Chem, 2013 The post-translational modifiers ubiquitin and small ubiquitin-related modifier (SUMO) regulate numerous critical signaling pathways and are key to controlling the cellular fate of proteins in eukaryotes. The attachment of ubiquitin and SUMO involves distinct, but related, machinery.
Novoselova TV +3 more
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Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome [PDF]
Proceedings of the National Academy of Sciences, 2010 The polycomb repressive complex (PRC) 1 protein Ring1B is an ubiquitin ligase that modifies nucleosomal histone H2A, a modification which plays a critical role in regulation of gene expression.
Zaaroor-Regev, Daphna +8 more
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Charakterisierung von Herc2 und seiner Interaktion mit der Ubiquitin-Protein-Ligase E6-AP [PDF]
, 2006 Ursprünglich wurde E6-AP (E6-assoziiertes Protein) als zellulärer Partner des E6-Onkoproteins Krebs-assoziierter humaner Papillomviren isoliert. In diesem Komplex fungiert E6-AP als eine Ubiquitin-Protein-Ligase, welche das Tumorsuppressorprotein p53 für
Kogel, Ulrike
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UBE3A/E6-AP mutations cause Angelman syndrome [PDF]
Nature Genetics, 1996 Angelman syndrome (AS), characterized by mental retardation, seizures, frequent smiling and laughter, and abnormal gait, is one of the best examples of human disease in which genetic imprinting plays a role. In about 70% of cases, AS is caused by de novo maternal deletions at 15q11-q13 (ref. 2).
T, Kishino, M, Lalande, J, Wagstaff
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Tristetraprolin and E6-AP: Killing the messenger in cervical cancer [PDF]
Cell Cycle, 2010 Cervical cancer, a human papillomavirus (HPV)-induced malignancy, is the most common gynecological cancer worldwide. Infection of cervical epithelium with highrisk HPV subtypes-16 and -18 followed by HPV integration into the host genome allows for constitutive expression of viral oncoproteins.
Sandhya, Sanduja, Dan A, Dixon
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Identifizierung und Charakterisierung von potentiellen Interaktionspartnern der Ubiquitin-Protein-Ligase E6-AP [PDF]
, 2002 Die menschliche Ubiquitin-Protein-Ligase E6-AP gehört zur Familie der HECT-Ligasen und ubiquitiniert im Komplex mit dem E6-Onkoprotein Krebs-assoziierter humaner Papillomviren (HPV) den Tumorsuppressor p53 und markiert ihn damit für den proteasomalen ...
Glockzin, Sandra
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Mutation screening of the UBE3A /E6-AP gene in autistic disorder [PDF]
Molecular Psychiatry, 1999 Previous reports of individuals with autistic disorder with maternal duplications of 15q11-q13, the Prader-Willi/Angelman syndrome region, suggest this area as a source of candidate genes in autistic disorder. Maternal truncation mutations in UBE3A, which encodes for E6-AP ubiquitin-protein ligase, have been shown to cause Angelman syndrome, which can ...
J, Veenstra-VanderWeele +3 more
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