Results 1 to 10 of about 327,500 (191)

Isoform-specific degradation of PR-B by E6-AP is critical for normal mammary gland development. [PDF]

Mol Endocrinol, 2010
E6-associated protein (E6-AP), which was originally identified as an ubiquitin-protein ligase, also functions as a coactivator of estrogen (ER-α) and progesterone (PR) receptors.
Ramamoorthy S, Dhananjayan SC, Demayo FJ, Nawaz Z.   +3 more
europepmc   +4 more sources

Autism and Human Papillomavirus (HPV) E6: A Comprehensive Review [PDF]

Iranian Journal of Psychiatry
Objective: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication impairments, restricted interests, and repetitive behaviors.
Najmeh Sheikhi, Faezeh Hajizadeh, Jamal Sarvari, Zahra Bazi, Iliad Moradi, Abdolvahab Moradi   +5 more
doaj   +2 more sources

Regulation of Peroxisome Proliferator-Activated Receptors by E6-Associated Protein [PDF]

PPAR Research, 2008
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors (NRs) that regulate genes involved in lipid and glucose metabolism. PPAR activity is regulated by interactions with cofactors and of interest are cofactors with ubiquitin ligase ...
Lakshmi Gopinathan, Daniel B. Hannon, Russell W. Smith, Jeffrey M. Peters, John P. Vanden Heuvel   +4 more
doaj   +2 more sources

Post-translational control of IL-1β via the human papillomavirus type 16 E6 oncoprotein: a novel mechanism of innate immune escape mediated by the E3-ubiquitin ligase E6-AP and p53.

PLoS Pathogens, 2013
Infections with high-risk human papillomaviruses (HPVs) are causally involved in the development of anogenital cancer. HPVs apparently evade the innate immune response of their host cells by dysregulating immunomodulatory factors such as cytokines and ...
Martina Niebler, Xu Qian, Daniela Höfler, Vlada Kogosov, Jittranan Kaewprag, Andreas M Kaufmann, Regina Ly, Gerd Böhmer, Rainer Zawatzky, Frank Rösl, Bladimiro Rincon-Orozco   +10 more
doaj   +2 more sources

E3 ubiquitin protein ligase, E6-associated protein (E6-AP) regulates PI3K-Akt signaling and prostate cell growth. [PDF]

Biochim Biophys Acta, 2011
This study elucidates the role of E6-associated protein, E6-AP (a dual function steroid hormone receptor coactivator and ubiquitin-protein ligase) in the regulation of PI3K-Akt signaling pathway, prostate gland growth and proliferation.
Srinivasan S, Nawaz Z.
europepmc   +2 more sources

ERα phosphorylation at Y537 by Src triggers E6-AP-ERα binding, ERα ubiquitylation, promoter occupancy, and target gene expression.

Mol Endocrinol, 2012
Many transcription factors undergo transcription-coupled proteolysis. Although ligand binding activates ubiquitin proteolysis of estrogen receptor α (ERα), mechanisms governing this and its relationship to transcriptional activation were unclear.
Sun J, Zhou W, Kaliappan K, Nawaz Z, Slingerland JM.   +4 more
europepmc   +2 more sources

TIP-1 is a Degradation Target of HPV-16 E6 [PDF]

Egyptian Journal of Cancer and Biomedical Research, 2023
Background: The high risk Human Papilloma virus E6 oncoprotein plays an essential role in the development and maintenance of malignancy through its ability to target several PDZ domain containing proteins one of them is a small PDZ protein called Tax ...
miranda thomas, paola Massimi, Lawrence Banks, mona elsherbeny   +3 more
doaj   +1 more source

Targeting Aberrant Expression of STAT3 and AP-1 Oncogenic Transcription Factors and HPV Oncoproteins in Cervical Cancer by Berberis aquifolium

Frontiers in Pharmacology, 2021
Background: Present study examines phytochemical preparation that uses berberine’s plant source B. aquifolium root for availability of similar anti-cervical cancer (CaCx) and anti-HPV activities to facilitate repurposing of the B.
Tejveer Singh, Arun Chhokar, Kulbhushan Thakur, Nikita Aggarwal, Pragya Pragya, Joni Yadav, Tanya Tripathi, Mohit Jadli, Anjali Bhat, Pankaj Gupta, Anil Khurana, Alok Chandra Bharti   +11 more
doaj   +1 more source

Ubiquitin-protein ligase E3A (UBE3A) mediation of viral infection and human diseases

Virus Research, 2023
The Ubiquitin-protein ligase E3A, UBE3A, also known as E6-associated protein (E6-AP), is known to play an essential role in regulating the degradation of various proteins by transferring Ub from E2 Ub conjugating enzymes to the substrate proteins ...
Pankaj Chaudhary, Jessica Proulx, In-Woo Park   +2 more
doaj   +1 more source

Proteasomal degradation of p53 by human papillomavirus E6 oncoprotein relies on the structural integrity of p53 core domain. [PDF]

PLoS ONE, 2011
The E6 oncoprotein produced by high-risk mucosal HPV stimulates ubiquitinylation and proteasome-dependent degradation of the tumour suppressor p53 via formation of a trimeric complex comprising E6, p53, and E6-AP.
Xavier Bernard, Philip Robinson, Yves Nominé, Murielle Masson, Sebastian Charbonnier, Juan Ramon Ramirez-Ramos, Francois Deryckere, Gilles Travé, Georges Orfanoudakis   +8 more
doaj   +1 more source