Results 41 to 50 of about 193,083 (310)

Intranasal delivery of shRNA to knockdown the 5HT-2A receptor enhances memory and alleviates anxiety

Translational Psychiatry
Short-hairpin RNAs (shRNA), targeting knockdown of specific genes, hold enormous promise for precision-based therapeutics to treat numerous neurodegenerative disorders.
Troy T. Rohn, Dean Radin, Tracy Brandmeyer, Peter G. Seidler, Barry J. Linder, Tom Lytle, John L. Mee, Fabio Macciardi   +7 more
doaj   +1 more source

Use of bioelectrical impedance spectroscopy to provide a measure of body composition in sows

Animal, 2021
The ability to accurately estimate fat mass and fat-free mass (FFM) has the potential to improve the way in which sow body condition can be managed in a breeding herd. Bioelectrical impedance spectroscopy (BIS) has been evaluated as a practical technique
T.L. Muller, L.C. Ward, K.J. Plush, J.R. Pluske, D.N. D'Souza, W.L. Bryden, R.J. van Barneveld   +6 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Importance of the interplay between land cover and topography in modeling habitat selection

Ecological Indicators
Anthropogenic land cover change is one of the greatest threats to the persistence of organisms. Therefore, identifying and safeguarding optimal land covers for declining organisms is a major challenge of the Anthropocene.
Haruki Natsukawa, Hiroki Yuasa, Masao Fujisaki, Takayuki Kobayashi, Hiroyoshi Maruyama, Katsuji Masukawa, Kouichi Nunokawa, Hitoshi Saito, Ginichi Sato, Luke J. Sutton, Makoto Takahashi, Takeshi Toba, Sumio Washizawa, Masafumi Yanagawa, Kunihiro Yoshida, Fabrizio Sergio   +15 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Identification of sex-specific SNPS in burbot Lota lota using RAD sequencing: conservation and management applications

Fisheries and Aquatic Sciences, 2019
The development of sex-specific genetic assays in a species provides both a method for identifying the system of sex determination and a valuable tool to address questions of conservation and management importance.
Ninh V. Vu, Daniel L. Eardley, Thomas A. Delomas, Matthew R. Campbell   +3 more
doaj   +1 more source

Mating systems and predictors of relative reproductive success in a Cutthroat Trout subspecies of conservation concern

Ecology and Evolution, 2021
Mating systems and patterns of reproductive success in fishes play an important role in ecology and evolution. While information on the reproductive ecology of many anadromous salmonids (Oncorhynchus spp.) is well detailed, there is less information for ...
John S. Hargrove, Jesse McCane, Curtis J. Roth, Brett High, Matthew R. Campbell   +4 more
doaj   +1 more source

EAGLE [PDF]

Proceedings of the fifth conference on Applied natural language processing Descriptions of system demonstrations and videos -, 1997
Over the course of two summer projects, we developed a general purpose natural language system which advances the state-of-the-art in several areas. The system contains demonstrated advancements in part-of-speech tagging, end-of-sentence detection, and coreference resolution.
Breck Baldwin, Christine Doran, Jeffrey C. Reynar, Michael Niv, B. Srinivas   +4 more
openaire   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source