Results 51 to 60 of about 171,863 (295)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Mitochondrial Phylogeny and Systematics of Palearctic Eagles
Пернатые хищники и их охрана, 2023 The eagles sensu lato are a polyphyletic group of large raptors represented in the Palearctic realm by 13 species belonging to two subfamilies: Aquilinae (true Eagles) and Haliaeetinae (Sea Eagles).
Ivan J. Starikov, Michael Wink
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Global Ecology and Conservation, 2022 Large raptors are the most mobile top predators in fragmented landscapes and, consequently, they are key components of ecosystems. However, large raptors (e.g.
Santiago Zuluaga +3 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The European Zoological Journal, 2022 The black stork Ciconia nigra is a rare species of bird that inhabits old forests near wetlands. The early 21st century has brought a regress of its population in north-eastern Poland.
G. Zawadzki +3 more
doaj +1 more source
Constraining the Location of Microlensing Objects by using the Finite Source Effect in EAGLE events [PDF]
, 2000 We propose a new method to constrain the location of microlensing objects using EAGLE (Extremely Amplified Gravitational LEnsing) events. We have estimated the rate of EAGLE events by taking the finite-source effect in to account. We found that the EAGLE
Afonso C. +6 more
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Importance-satisfaction analysis for marine-park hinterlands: A Western Australian case study [PDF]
, 2007 Tourist use of national and marine parks continues to increase worldwide. Effective management depends on being able to evaluate the quality of visitors' experiences, as well as protecting the natural environment.
Moore, S.A., Tonge, J.
core +2 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source