Results 131 to 140 of about 563,854 (280)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Small and Close-in Planets are Uncommon Around A-type Stars
The Astronomical JournalThe Kepler and K2 missions enabled robust calculations of planet occurrence rates around FGKM-type stars. However, these missions observed too few stars with earlier spectral types to tightly constrain the occurrence rates of planets orbiting hotter ...
Steven Giacalone, Courtney D. Dressing
doaj +1 more source
δ Circini: A massive hierarchical triple system with an eclipsing binary
Astronomy & Astrophysicsδ Circini is known to be a massive multiple system containing a 3.9 d inner eclipsing binary in a slightly elliptical orbit exhibiting slow apsidal motion and a distant tertiary with a probable period of 1644 d.
Švrčková J. +8 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Recent Star Formation in Nearby Early-type Galaxies
, 2007 8 pages, to appear in "Pathways Through an Eclectic Universe", J. H. Knappen, T. J. Mahoney, and A. Vazedekis (Eds.), ASP Conf.
Sarzi, M +11 more
openaire +3 more sources
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The Secondary Component of the Extremely Low Mass Ratio Massive Binary HD 165246 Revealed by GHOST
The Astrophysical JournalIn the pursuit of understanding the multiplicity of massive stars, the OWN Survey has undertaken spectroscopic monitoring of hundreds of targets over the past 20 yr.
C. N. Rodriguez +30 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source