Results 121 to 130 of about 11,496,581 (289)

OB Stars Identified in the LAMOST Data Release 10

The Astrophysical Journal Supplement Series
A large sample of OB stars plays an important role in studying the stellar parameters of massive stars, as well as the formation and evolution of the Milky Way.
Guang Yang, Zhicun Liu, Xiao-Long Wang, Yanjun Guo, Wenyuan Cui   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

A Spectroscopic Survey of Metal-poor OB Stars in Local Dwarf Galaxy NGC 3109

The Astrophysical Journal
As JWST uncovers increasingly strong evidence that metal-poor, massive stars in early galaxies dominated reionization, observational constraints on the properties of such stars are more relevant than ever before.
Abby Mintz, O. Grace Telford, Evan N. Kirby, John Chisholm, Kristen B. W. McQuinn, Danielle A. Berg   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Toward Early-type Eclipsing Binaries as Extragalactic Milestones: First Calibration of the SBCR from O- and B-type Stars in Detached Eclipsing Binaries

The Astrophysical Journal Letters
To measure precise distances beyond the Magellanic Clouds and determine an accurate value of the Hubble constant, eclipsing binary systems composed of early-type stars can play a crucial role.
Mónica Taormina, G. Pietrzyński, B. Pilecki, R.-P. Kudritzki, D. Graczyk, J. Puls, M. Górski   +6 more
doaj   +1 more source

Pulsation in Hot Main-Sequence Stars: Comparison of Observations with Models

Universe
The locations of hot pulsating variables in the H–R diagram are found using the effective temperatures derived from spectroscopic analysis and luminosities from Gaia parallaxes.
Luis A. Balona
doaj   +1 more source