Results 111 to 120 of about 11,496,581 (289)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

First Observation of the Complete Rotation Period of the Ultraslowly Rotating Magnetic O Star HD 54879

The Astrophysical Journal
HD 54879 is the most recently discovered magnetic O-type star. Previous studies ruled out a rotation period shorter than 7 yr, implying that HD 54879 is the second most slowly rotating known magnetic O-type star.
C. Erba, C. P. Folsom, A. David-Uraz, G. A. Wade, S. Seadrow, S. Bellotti, L. Fossati, V. Petit, M. E. Shultz   +8 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Differential rotation in early type stars

, 2006
Using 2D models of rotating stars, the interferometric measurements of alpha Eri and its fundamental parameters corrected for gravitational darkening effects we infer that the star might have a core rotating 2.7 times faster than the surface. We explore the consequences on spectral lines produced by surface differential rotation combined with the ...
Zorec, J., Frémat, Y., Domiciano de Souza, A.   +2 more
openaire   +3 more sources

Binarity at LOw Metallicity (BLOeM)

Astronomy & Astrophysics
The Binarity at LOw Metallicity (BLOeM) survey is an ESO large programme designed to obtain multi-epoch spectroscopy for 929 massive stars in the Small Magellanic Cloud (SMC).
Lennon D. J., Berlanas S. R., Herrero A., Britavskiy N., Dufton P. L., Langer N., Jin H., Schootemeijer A., Menon A., Bestenlehner J., Crowther P., Vink J. S., Bodensteiner J., Shenar T., Deshmukh K., Villaseñor J. I., Patrick L., Najarro F., de Koter A., Mahy L., Bowman D. M., Bobrick A., Evans C. J., Gull M., Holgado G., Katabi Z., Kubát J., Marchant P., Pauli D., Pawlak M., Renzo M., Rocha D. F., Sander A. A. C., Sayada T., Simón-Díaz S., Stoop M., Valli R., Wang C., Xu X.-T.   +38 more
doaj   +3 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

X-Shooting ULLYSES: Massive stars at low metallicity

Astronomy & Astrophysics
Context. Hot massive stars lose mass through radiation-driven winds, producing significant chemical, radiative, and mechanical feedback in the surrounding environment.
Alkousa T., Crowther P. A., Bestenlehner J. M., Sana H., Tramper F., Vink J. S., Najarro F., Sander A. A. C., Bernini-Peron M., Oskinova L., van Loon J. Th., Kuiper R.   +11 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source