Results 131 to 140 of about 40,670 (264)

Toward Early-type Eclipsing Binaries as Extragalactic Milestones: First Calibration of the SBCR from O- and B-type Stars in Detached Eclipsing Binaries

The Astrophysical Journal Letters
To measure precise distances beyond the Magellanic Clouds and determine an accurate value of the Hubble constant, eclipsing binary systems composed of early-type stars can play a crucial role.
Mónica Taormina, G. Pietrzyński, B. Pilecki, R.-P. Kudritzki, D. Graczyk, J. Puls, M. Górski   +6 more
doaj   +1 more source

Pulsation in Hot Main-Sequence Stars: Comparison of Observations with Models

Universe
The locations of hot pulsating variables in the H–R diagram are found using the effective temperatures derived from spectroscopic analysis and luminosities from Gaia parallaxes.
Luis A. Balona
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Spectroscopic and Photometric Analysis of the HW Vir Star PTF1 J011339.09+225739.1

Open Astronomy, 2018
HW Vir systems are rare eclipsing binary systems including a subdwarf B star (sdB) with a faint companion, mostly M-dwarfs. Up to now, 19 HW Vir systems have been published, three of them with substellar companions. We report the spectroscopic as well as
Wolz Maximilian, Kupfer Thomas, Drechsel Horst, Heber Ulrich, Irrgang Andreas, Hermes J.J., Bloemen Steven, Levitan David, Dhillon Vik, Marsh TomR.   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Systematic Search for Blue Hypervelocity Stars from LAMOST Survey

The Astrophysical Journal
Hypervelocity stars (HVSs) represent a unique class of objects capable of escaping the gravitational pull of the Milky Way due to extreme acceleration events, such as close encounters with the supermassive black hole at the Galactic center (GC ...
Yongkang Sun, Yang Huang, Jifeng Liu, Haozhu Fu, Huawei Zhang, Yinbi Li, Cuihua Du, Jianrong Shi, Xiao Kong   +8 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mass, Luminosity, and Stellar Age of Early-type Stars from the LAMOST Survey

The Astrophysical Journal Supplement Series
Mass ( M ) and luminosity ( L ) are fundamental parameters of stars but can only be measured indirectly. Typically, effective temperature ( T _eff ), surface gravity ( $\mathrm{log}\ g$ ), and metallicity ([M/H]) are derived from stellar spectra, then M ,
Qida Li, Jianping Xiong, Jiao Li, Yanjun Guo, Zhanwen Han, Xuefei Chen, Chao Liu   +6 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source