Results 91 to 100 of about 3,155,969 (318)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Smallpox vaccination: an early start of modern medicine in America
Journal of Community Hospital Internal Medicine Perspectives, 2017 Smallpox was eradicated by the World Health Organization in 1980. Before its eradication thedisease had a mortality rate upwards of 50% and had a significant impact on society.
Dan Liebowitz
doaj +1 more source
PASTA OR PARADIGM: THE PLACE OF ITALIAN-AMERICAN WOMEN IN POPULAR FILM [PDF]
, 1979 The year is 1930, the film is Little Caesar, and Hollywood begins its long and often irresponsible tradition of portraying the Italian-American male as gangster, thug, sociopath.
Golden, Daniel
core +2 more sources
Counting Guns in Early America [PDF]
, 2005 Probate inventories, though perhaps the best prevailing source for determining ownership patterns in early America, are incomplete and fallible.
Heather, Justin Lee, Lindgren, James T.
core +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Young Black America Part Four: The Wrong Way to Close the Gender Wage Gap [PDF]
, 2015 Young blacks in America have had significant improvements in educational attainment since the early 1980s. They are completing high school and college at higher rates than in the past, which has helped to mitigate some of the negative employment effects ...
Cherrie Bucknor
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Globalization Dynamics in Latin America: South Cone and Iberian Investments [PDF]
This paper analyzes in perspective the integration process through which Latin America, specially the South Cone, went through during the long formation process of the world economy, since the expansion that brought Latin America to capitalist ...
Cezar Guedes, Mário Gómez
core