Results 81 to 90 of about 7,818,648 (307)

Management of severe traumatic brain injury in regions with limited resources

, 2021
Importance: Severe traumatic brain injury (sTBI) is a critical health problem in regions of limited resources (RLRs). Younger populations are among the most impacted. The objective of this review is to analyze recent consensus-based algorithms, protocols
Griswold, Dylan Paul, Rabinstein, Alejandro A., Godoy, Daniel Agustín, Jibaja, Manuel, Rubiano, Andrés Mariano, Andres M. Rubiano, Manuel Jibaja, Daniel Agustin Godoy, Dylan P. Griswold, Alejandro A. Rabinstein   +9 more
core   +1 more source

Effect of Nursing Interventions on Early Identification and Management of Paroxysmal Sympathetic Hyperactivity of Patients with Traumatic Brain Injury [PDF]

Tanta Scientific Nursing Journal
Background: Early detection of Paroxysmal Sympathetic Hyperactivity intraumatic brain injury cases is essential to prevent complications and improveoutcomes, with nurses playing a key frontline role in its timely identification andmanagement.
Rokia El Nagar, Shaimaa Abdelrahman, Safaa Ahmed   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Developing Core Sets for Persons With Traumatic Brain Injury Based on the International Classification of Functioning, Disability, and Health [PDF]

, 2009
The authors outline the process for developing the International Classification of Functioning, Disability, and Health (ICF) Core Sets for traumatic brain injury (TBI).
Stucki, Gerold, Barnes, Michael, Tate, Robyn, Bernabeu, Montserrat, Lopez, Raquel, Kostanjsek, Nenad, Cieza, Alarcos, Whyte, John, Zasler, Nathan, Ward, Anthony, Laxe, Sara, Reed, Geoffrey   +11 more
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Circulating tight-junction proteins are potential biomarkers for blood–brain barrier function in a model of neonatal hypoxic/ischemic brain injury

Fluids and Barriers of the CNS, 2021
Background Neonatal encephalopathy often leads to lifelong disabilities with limited treatments currently available. The brain vasculature is an important factor in many neonatal neurological disorders but there is a lack of diagnostic tools to evaluate ...
E. Axel Andersson, Carina Mallard, C. Joakim Ek   +2 more
doaj   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

A technical review of dynamic brain functional imaging combined with EEG spectral parameters in the screening of early-stage brain injury

Frontiers in Medical Technology
BackgroundEarly-stage brain injury encompasses subtypes such as mild traumatic brain injury (mTBI), silent stroke and subclinical brain injury. It is characterised by negative imaging findings, subtle symptoms and a high risk of long-term neurological ...
Hongmei Ruan, Hongmei Ruan, Liqing Liao, Yuan Zhang, Zicai Liu, Qiang Wu   +5 more
doaj   +1 more source