Results 91 to 100 of about 23,513,968 (309)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Examining science, technology and engineering content in early learning guidelines: a count and content review and analysis

International Journal of Child Care and Education Policy
Early Learning Guidelines (ELGs) support early childhood educators, administrators, and professionals in developing and implementing early learning experiences to support young children’s knowledge and skill development. Previous reviews of ELGs examined
Jessica A. Amsbary, Ann M. Sam, Hsiu-wen Yang, Elica Sharifnia, Kellen Reid, Chih-Ing Lim, Megan Vinh   +6 more
doaj   +1 more source

Needs Analysis of Teaching Aids to Enhance Monosyllabic English Reading Skills among Six-Year-Old Preschool Children

Asian Journal of Assessment in Teaching and Learning
Teaching English monosyllabic reading is a crucial component in fostering early literacy and cognitive development among preschool children. This study aims to identify the level of need for teaching aids that can effectively support six-year-old ...
Intan Farahana Abdul Rani, Nur Mizan Qistyna   +1 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

National outcome measures for early childhood development—phase 2: scoping paper [PDF]

, 2014
This report presents the results of Phase 2 of the National Outcome Measures for Early Childhood Development project. It identifies potential indicators for 5 indicator topic areas (child behavioural problems, peer relationships, racism, school ...
Australian Institute of Health and Welfare
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

DEECD Early Childhood Intervention Reform Project [PDF]

, 2010
This literature review was commissioned by the Office for Children and Early Childhood Development, Department of Education and Early Childhood Development (DEECD), as part of its Early Childhood Intervention Services (ECIS) Reform Project (Stage 2 ...
June McLoughlin, John Forster, Anne Kennedy, Tim G. Moore, Susana Gavidia-Payne   +4 more
core  

Childcare providers’ attitudes, knowledge, and practice related to developmental monitoring to promote early identification and referral

, 2019
Although intervening early can improve child and family outcomes when a child has a developmental disability, most children with developmental delays are not identified prior to school entry.
Pizur-Barnekow, Kris, Chödrön, Gail, Barger, Brian, Puk-Ament, Alexandra, Viehweg, Stephan   +4 more
core   +1 more source

Resilience: supporting children’s self-regulation in infant and toddler classrooms

Frontiers in Psychology
IntroductionResilience is a process that develops as a complex transaction as children experience and shape their social-ecological contexts. The dynamic development of self-regulation is an aspect of resilience that has received increased attention as a
Diane M. Horm, Shinyoung Jeon, Denise Vega Ruvalcaba, Sherri Castle   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source