Results 111 to 120 of about 23,513,968 (309)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A person-centered examination of adverse childhood experiences and associated distal health, mental health, and behavioral outcomes in the United Arab Emirates

BMC Psychiatry
Background An increasing body of evidence highlights the utility of examining adverse childhood experiences (ACEs) utilizing person-centered analytical approaches, particularly for understanding the organization and co-occurrence of ACEs, and their ...
Anthony Murphy, Iffat Elbarazi, Neal Horen, Zeina Ismail-Allouche, Toby Long, Adam McNeill, Cairo Arafat, Dawn England   +7 more
doaj   +1 more source

Designing Inclusive Computational Thinking Learning Trajectories for the Youngest Learners

Education Sciences
Foundational thinking for later use of technology, particularly coding, is necessary for an inclusive and sustainable future. Inclusive practices beginning in early childhood recognize children’s innate development of computational thinking—sequencing ...
Shannon Stark Guss, Douglas H. Clements, Elica Sharifnia, Julie Sarama, Adam Holland, Chih-Ing Lim, Megan Vinh   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Exploring the Complexity of Children’s Math and Vocabulary Learning: The Role of Cognitive, Dispositional, and Parental Factors

Behavioral Sciences
Early mathematical and vocabulary skills serve as critical foundations for academic success, yet the mechanisms underlying their development remain complex.
Zhengqing Li, Keting Chen, Kevin P. Rosales, Jingjing Xu, Lisa Looney, Xin Zhou   +5 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

The socio-economic gradient in early child outcomes: evidence from the Millennium Cohort Study [PDF]

This paper shows that there are large differences in cognitive and socio-emotional development between children from rich and poor backgrounds at the age of 3, and that this gap widens by the age of 5.
Lorraine Dearden, Kathy Sylva, Luke Sibieta   +2 more
core  

Inequalities in Early Childhood outcomes: what lies beneath [PDF]

, 2014
This article uses the Australian Early Development Index to shine a light on inequity in child health and development. Introduction: Child health inequalities exist in all western countries including Australia and constitute a significant and ...
Sharon Goldfeld
core  

Fathers’ perspectives on brain health education and the promotion of dementia risk reduction for their primary school aged children

BMC Public Health
Background Fathers occupy a distinctive and influential role in shaping children’s developmental trajectories and health-related behaviours. However, their perspectives on brain health education and dementia risk reduction remains largely absent from the
Joyce Siette, Andrew Gwilliam, Elisabeth Duursma   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source