Results 131 to 140 of about 9,881,930 (352)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Early Childhood Intervention. Rationale, Timing and Efficacy [PDF]

This paper provides a brief review of the economic rationale for investing in early childhood. It discusses the optimal timing of intervention, with reference to recent work in developmental neuroscience, and asks how early is early?
Colm Harmon, James J. Heckman, Orla Doyle, Richard E. Tremblay   +3 more
core  

Family at the Center [PDF]

, 2015
To better understand how family engagement supports school readiness in Los Angeles County, The David and Lucile Packard Foundation and the LA Partnership for Early Childhood Investment convened an advisory group of early childhood leaders and ...

core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Psychometric properties of the Chinese version of the attachment insecurity screening inventory 2–5 years: a preliminary study

BMC Psychology
Background Secure attachment bonds between children and their parents are crucial for their positive developmental outcomes. In attachment-based treatment, there are few instruments available for identifying insecure child-caregivers attachment ...
Jingjing Zhu, Zhuyi Li, Siyuan Zhu, Yan Li   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Student and supervisor perspectives on engaging in collaborative thesis supervision as an online group

New Zealand Journal of Teachers' Work
In this text we relfect on an online group supervision within a Master of Education postgraduate programme. Foregrounding the importance of reflexivity (Ortlipp, 2008) four students and their supervisor retrospectively critiqued the online group ...
Tiffany Williams, Debbie Ryder, Mae Befayed, Ranjani Lata, Shelley Auld   +4 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Examining family-preschool partnership: A literature review of the existing measures and their psychometric properties

Journal of Early Childhood Education Research
Family-preschool partnership is recognised as an important relationship between parents and teachers contributing to preschool child outcomes which has received increasing attention the last decades.
Theodora Margaritopoulou, Maria Tsitiridou-Evangelou, Athanasios Gregoriadis, Vasilis Grammatikopoulos   +3 more
doaj   +1 more source