Results 71 to 80 of about 7,542,497 (361)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Play-Responsive Teaching in Early Childhood Education

International Perspectives on Early Childhood Education and Development, 2019
This open access book develops a theoretical concept of teaching that is relevant to early childhood education, and based on children’s learning and development through play.
Niklas Pramling, Cecilia Wallerstedt, Pernilla Lagerlöf, Camilla Björklund, Anne Kultti, Hanna Palmér, Maria Magnusson, S. Thulin, Agneta Jonsson, I. Samuelsson   +9 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Early childhood caries, climate change and the sustainable development goal 13: a scoping review

BMC Oral Health
Background Sustainable development goal 13 centres on calls for urgent action to combat climate change and its impacts. The aim of this scoping review was to map the published literature for existing evidence on the association between the Sustainable ...
Morẹ́nikẹ́ Oluwátóyìn Foláyan, Robert J Schroth, Olunike Abodunrin, Ola B. Al-Batayneh, Arheiam Arheiam, Tshepiso Mfolo, Jorma I. Virtanen, Duangporn Duangthip, Carlos A Feldens, Maha El Tantawi   +9 more
doaj   +1 more source

Investing in Early Childhood

, 2013
A major puzzle of our times is the lack of any serious progress in equal opportunities, despite so much effort invested in the pursuit thereof. Tofully understand why, we need to identify more precisely the mechanisms at work. What is now well understood is that educational reforms, no matter how progressive and egalitarian in design, are ...
openaire   +2 more sources

Global and regional white matter development in early childhood

NeuroImage, 2019
White matter development continues throughout childhood and into early adulthood, but few studies have examined early childhood, and the specific trajectories and regional variation in this age range remain unclear.
Jess E. Reynolds, Melody N. Grohs, D. Dewey, C. Lebel   +3 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Association between early childhood caries and parental education and the link to the sustainable development goal 4: a scoping review

BMC Oral Health
Background The goal of the United Nations Sustainable Development Goal (SDG) 4 is to ensure inclusive and equitable quality education and promote lifelong learning opportunities for all.
Morenike Oluwatoyin Folayan, Elisa Maria Rosa de Barros Coelho, Imen Ayouni, Arthemon Nguweneza, Ola Barakat Al-Batayneh, Hamideh Daryanavard, Duangporn Duangthip, Ivy Guofang Sun, Arheiam Arheiam, Jorma I. Virtanen, Balgis Gaffar, Maha El Tantawi, Robert J Schroth, Carlos Alberto Feldens   +13 more
doaj   +1 more source

Central Dysmyelination in SSADH‐Deficient Humans and Mice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer, Henry H. C. Lee, Edward Yang, Cesar Alves, Mariarita Bertoldi, Caitlyn Fung, Spencer V. Steele, Eren Kule, Zijie Jin, Alexander Rotenberg, Jean‐Baptiste Roullet, Phillip L. Pearl   +11 more
wiley   +1 more source

Co-parenting, parental competence and problem behaviours in children: examining differential parental roles

Humanities & Social Sciences Communications
In recent years, the increase in child problem behaviours has become a significant public health concern. It is crucial to understand the complex dynamics between parental co-parenting, parenting competence, and child problem behaviours to develop ...
Baocheng Pan, Youli Wang, Chengli Zhao, Jiaxuan Miao, Yizhao Gong, Bowen Xiao, Yan Li   +6 more
doaj   +1 more source