Results 61 to 70 of about 747,201 (316)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
International Journal of Child Care and Education PolicyPlay is integral to early childhood development, fostering skills crucial for holistic growth. While the role of mothers supporting children’s play has been widely studied, there is limited research on fathers’ roles, despite evidence suggesting a ...
Tolulope Ojo +3 more
doaj +1 more source
Parenting Research in Indonesia: What We Have Done So Far
Buletin Psikologi, 2020 Parenting is one of the most important responsibilities that someone could bear as a parent, probably the most burdensome too. Regardless, several questions are still left unanswered by Indonesian scientists, what are the field of studies related to ...
Beatriks Novianti Kiling-Bunga +2 more
doaj +1 more source
MEDIA LEARNING FOR EARLY CHILDHOOD IN EARLY CHILDHOOD EDUCATION
Sensei International Journal of Education and Linguistic, 2021 Early Childhood Education is an effort to stimulate and stimulate children from birth to the age of six which is carried out by providing educational stimuli to help the growth and development of children, both physically and spiritually so that children are ready to enter further education. Early childhood is a group that is in a process of growth and
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Study on the Views about the Professional Evaluation for Early Childhood Nurses and Teachers [PDF]
, 2010 [[abstract]]Facing the multiple cultures and speedy development, a lot of people lose their confidence for the teachers’ profession. The teachers, hence need to promote themselves with professional abilities.
SHIOW-TSAI CHEN
core
BMC PsychologyMental health problems among children are a significant public health concern. Family dynamics and early educational environments are critical in shaping children’s mental health.
Youli Wang +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Parental co-parenting quality, children’s emotion regulation abilities, and prosocial behavior
BMC PsychologyObjective This study used latent profile analysis to explore latent profiles of parental coparenting quality and their relationships with children’s prosocial behavior, and to examine the mediating role of children’s emotion regulation abilities. Methods
Baocheng Pan +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source