Results 141 to 150 of about 12,626,452 (304)

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

open access: yesAdvanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae   +5 more
wiley   +1 more source

Hindrance stressors and turnover intentions among preschool teachers: The mediating role of work engagement and the moderating effect of meaningful work

open access: yesHeliyon
Background: Teacher turnover in preschool settings poses significant challenges to educational quality and stability. Understanding the factors that influence turnover intentions is crucial for developing effective retention strategies.
Jinghui Zhang, Yu Chen, Yige Xu, Yan Li
doaj   +1 more source

Early Childhood Education in Taiwan

open access: yes, 2017
This chapter discusses the development of early childhood education (ECE) in Taiwan. Kindergartens and daycare centers were initially set up to serve children from diverse families, often with little guidance on pedagogical principles.
Chen, EE   +5 more
core   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

open access: yesAdvanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li   +8 more
wiley   +1 more source

The relationship between social avoidance, behavioral self-regulation, and social adjustment among Chinese Kindergartners

open access: yesBMC Psychology
Research consistently indicates that socially avoidant children face challenges in adapting to social settings. This investigation aimed to explore the relationship between social avoidance and social adjustment and the moderating role of behavioral self-
Jingjing Zhu, Yu Shen, Yan Li
doaj   +1 more source

Adding To The Science Toolkit: Piloting Early Childhood Science Research Instruments In Australia

open access: yes, 2019
This pilot study trials three data collection instruments, namely the SciDoc, a teacher questionnaire and the Early Childhood Science Padlet. The tools were developed to examine high quality early childhood science assessment, teachers' attitudes towards
Cohrssen, CS   +2 more
core  

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

open access: yesAdvanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li   +10 more
wiley   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

open access: yesAdvanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun   +7 more
wiley   +1 more source

Digital citizenship education at the early childhood level: how is it implemented? A systematic review

open access: yesInternational Journal of Child Care and Education Policy
Users of technology are becoming younger over the years. Although the current generation of young children is often referred to as “digital natives,” this designation primarily reflects their intuitive engagement with digital tools rather than a ...
Lingxi Li   +2 more
doaj   +1 more source

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

open access: yesAdvanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia   +13 more
wiley   +1 more source

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