Results 171 to 180 of about 1,193,465 (362)

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function

open access: yesAdvanced Science, EarlyView.
Nestin localizes to the mitochondrial IMS through its MTS and the TOM20 import machinery. Within the mitochondria, Nestin interacts with Mic60 via its C‐terminal Tail3 domain. Loss of mitochondrial Nestin disrupts cristae architecture, leading to mitochondrial swelling, bioenergetic dysfunction, and ultimately the senescence of hMSCs.
Hainan Chen   +14 more
wiley   +1 more source

Relation between parental playfulness and child playfulness: mediating role of parent-child interaction

open access: yesHumanities & Social Sciences Communications
Playfulness plays a pivotal role in fostering individual development across cognitive, emotional, and creative domains. This study aims to investigate parental playfulness and playfulness among 681 Chinese children aged 3–6 years, including 356 boys (52 ...
Yonggang Wei   +4 more
doaj   +1 more source

MUSIC EDUCATION IN EARLY CHILDHOOD -AN ANALYSIS

open access: yesInternational Journal of Research -GRANTHAALAYAH, 2015
The main aim of education is not only giving the knowledge but education is the acquisition of the art of utilization of knowledge. This is an art very difficult to impart .The general purpose of education is the faster growth of individual knowledge in each human being. In human beings projection of individual is only possible by fine arts.
openaire   +2 more sources

Stage‐Resolved Phosphoproteomic Landscape of Mouse Spermiogenesis Reveals Key Kinase Signaling in Sperm Morphogenesis

open access: yesAdvanced Science, EarlyView.
The quantitative proteomic and phosphoproteomic profiling reveals dynamic phosphorylation regulation of sperm morphogenesis. Kinase‐substrate phosphorylation network and phosphorylation module analysis, followed by in vivo knockdown and knockout analysis, identify TTBK2 and CSNK1G1 as key regulators of morphogenesis, including head, flagellar, and ...
Tianyu Zhu   +25 more
wiley   +1 more source

Autologous Organoid‐T Cell Co‐Culture Platform for Modeling of Immune‐Mediated Drug‐Induced Liver Injury

open access: yesAdvanced Science, EarlyView.
A matrix‐free human liver organoid–T cell co‐culture platform enables modeling of immune‐mediated drug‐induced liver injury (iDILI). Using flucloxacillin and patient‐matched cells, this system recapitulates HLA‐B*57:01–restricted CD8⁺ T cell activation and hepatocyte damage.
Fadoua El Abdellaoui Soussi   +11 more
wiley   +1 more source

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