Results 81 to 90 of about 1,784,584 (391)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Working Families’ Access to Early Childhood Education [PDF]

, 2018
In this brief, using data from the Census Bureau, state administrative systems, and a Carsey survey of working parents, author Jessica Carson examines the child care landscape of the Upper Valley of New Hampshire and Vermont and links these findings to a
Carson, Jessica
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Psychometric properties of the Chinese version of the attachment insecurity screening inventory 2–5 years: a preliminary study

BMC Psychology
Background Secure attachment bonds between children and their parents are crucial for their positive developmental outcomes. In attachment-based treatment, there are few instruments available for identifying insecure child-caregivers attachment ...
Jingjing Zhu, Zhuyi Li, Siyuan Zhu, Yan Li   +3 more
doaj   +1 more source

Debunking the Myth of the Efficacy of “Push-down Academics”: How Rigid, Teacher-Centered, Academic Early Learning Environments Dis-Empower Young Children [PDF]

, 2018
The increased emphasis on higher academic standards in Early Childhood Education has changed the instructional landscape and developed myths of quality learning.
Harmon, Flora, Viruru, Radhika
core   +1 more source

The professional knowledge that counts in Australian contemporary early childhood teacher education [PDF]

, 2010
Australia is typical of many western countries where the provision of quality early childhood services has become a government priority. The government initiatives in Australia include repeated demands for 'well-qualified' early childhood educators. As a
Barnett R., Beatty B., Bernstein B., Blackmore J., Bredekamp S., Brennan D., Britzman D., Burman E., Cannella G.S., Cochran-Smith M., Cochran-Smith M., Cullen J., Dahlberg G., Dawkins J., Delpit L., Ellsworth E., Fleer M., Foucault M., Gahan D., Gibbons M., Grieshaber S., Groundwater-Smith S., Hill S., Homes B., Kessler S., MacNaughton G., Marshall J., McDevitt T., Meredyth D., Press F., Rose N., Silin J., Singh P., Susan Krieg, Thomas R., Walkerdine V., Whitehead K., Whitehead K.   +37 more
core   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Examining family-preschool partnership: A literature review of the existing measures and their psychometric properties

Journal of Early Childhood Education Research
Family-preschool partnership is recognised as an important relationship between parents and teachers contributing to preschool child outcomes which has received increasing attention the last decades.
Theodora Margaritopoulou, Maria Tsitiridou-Evangelou, Athanasios Gregoriadis, Vasilis Grammatikopoulos   +3 more
doaj   +1 more source

Early years workforce strategy [PDF]

This report sets out a vision agreed by all governments in Australia to build and support the early childhood education and care profession both in the short term and into the future.
Standing Council on School Education and Early Childhood
core  

Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug‐Resistant Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To develop a novel deep‐learning model of clinical DWI tractography that can accurately predict the general assessment of epilepsy severity (GASE) in pediatric drug‐resistant epilepsy (DRE) and test if it can screen diverse neurocognitive impairments identified through neuropsychological assessments.
Jeong‐Won Jeong, Min‐Hee Lee, Hiroshi Uda, Yoon Ho Hwang, Michael Behen, Aimee Luat, Csaba Juhász, Eishi Asano   +7 more
wiley   +1 more source