Results 101 to 110 of about 859,028 (310)
ELABELA Targets Mitochondria to Modulate Heart Development
Advanced Science, EarlyView.The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang +22 more
wiley +1 more source
To be an educator in a day care setting : conceptions and educational practices [PDF]
, 2012 The “Day Care Project” is a group of professionals linked to the childhood education field that aims to reflect and investigate early childhood in the day care context.
Correia, Sónia +2 more
core
Advanced Science, EarlyView.An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang +10 more
wiley +1 more source
Long-Term Effects of Early Childhood Care and Education [PDF]
This paper critically reviews what we know about the long-term effects of parental leave and early childhood education programs. We find only limited evidence that expansions of parental leave durations improved long-run educational or labor market ...
Ruhm, Christopher J., Waldfogel, Jane
core
Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs
Advanced Science, EarlyView.Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou +22 more
wiley +1 more source
臺灣教育社會學研究, 2007 幼兒資訊學習在臺灣幼教現場中未獲共識，但資訊科技對於幼兒認知思考、社會性發展與探究自然等能力之提升，成效不容忽視。本研究以幼兒資訊素養為主軸，探討幼兒在資訊科技的近用、應用，以及參與社會面向之表徵，涵蓋接觸資訊科技的機會、操作與使用資訊科技，以及對於資訊科技在其未來成長和參與社會活動等層面之理解及實踐。本研究聚焦在教育社會學的分析角度，且在文獻分析與教師訪談結果的基礎上，以教育機會均等與社會公平正義原則為原則，分別從近用機會、技術本位與主體性等批判面向提出具體的選擇策略以為因應 ...
陳儒晰 Ru-Si Chen +1 more
doaj
Caring about Early Childhood Education
, 2023 Early Childhood Education (ECE) is a broad term encompassing the care and education of children in the years before the commencement of primary school education. The purpose of ECE as the beginning of children’s educational journey versus childcare for working parents is widely contested, contributing to a care and education dichotomy within the sector.
openaire +1 more source
Advanced Science, EarlyView.AUTACE is a bifunctional nanoplatform that integrates tumor targeting, immune engagement, and on‐demand KRAS degradation. It targets KRAS/TP53 co‐mutant tumors via TP53‐specific TCRs, elicits antitumor CD8+ T‐cell responses through surface anti‐CD3 antibodies, and uses low‐intensity focused ultrasound (LIFU) to trigger controlled release of the KRAS ...
Luo Li +6 more
wiley +1 more source
“I love my work but...” The Professionalization of Early Childhood Education [PDF]
, 2013 There are two separate but related issues that have challenged advocates, researchers and practitioners in the field of early education and care work for decades : improving the quality of children’s programs and increasing the wages and benefits of the ...
Boyd, Margaret
core +1 more source
Advanced Science, EarlyView.The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen +11 more
wiley +1 more source