Results 131 to 140 of about 185,568 (314)

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

open access: yesAdvanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae   +5 more
wiley   +1 more source

Self-actualization and its psychosocial determinants among community health workers in rural Taiwan: a cross-sectional study

open access: yesBMC Psychology
Background Community health workers (CHWs) frequently operate in resource-limited rural environments where high work demands and persistent psychosocial stressors may challenge psychological functioning.
Yao-Mei Chuang, Wei-Hsiang Huang
doaj   +1 more source

Mothers' perspectives on learning through play in the home

open access: yes, 2016
Research in the field of early childhood education and care (ECEC) indicates that if educators can align their perspectives and practices with families' perspectives, children's educational outcomes will improve.
Colliver, Yeshe
core  

DEECD Early Childhood Intervention Reform Project [PDF]

open access: yes, 2010
This literature review was commissioned by the Office for Children and Early Childhood Development, Department of Education and Early Childhood Development (DEECD), as part of its Early Childhood Intervention Services (ECIS) Reform Project (Stage 2 ...
June McLoughlin   +4 more
core  

Multilingual learning environments in early childhood education in Finland [PDF]

open access: yes
Increasing linguistic diversity creates a need to construct early learning environments as spaces where children’s whole multilingual repertoires are represented.
Repo, Elisa   +3 more
core   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

open access: yesAdvanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li   +8 more
wiley   +1 more source

A snapshot of 40 years in early childhood education and care through oral histories [PDF]

open access: yes, 2013
The year 2012 marked 40 years since the introduction of the Child Care Act 1972 and the federal government introduced financial support for the provision of child care services in Australia.
Cobb-Moore, Charlotte   +2 more
core  

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

open access: yesAdvanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li   +10 more
wiley   +1 more source

Advancements in diagnosis, preventive care, and future directions in the holistic management of pediatric asthma

open access: yesFrontiers in Pediatrics
Pediatric asthma is a highly prevalent chronic respiratory disorder characterized by airway inflammation, hyperreactivity, and variable airflow limitation, resulting in significant global health and socioeconomic burdens. Advances in diagnosis, including
Wenwen Guo, Kangjian Li
doaj   +1 more source

Early childhood education and care in Aotearoa/New Zealand: history and feature

open access: yes, 2018
Since the 1990s, New Zealand/Aotearoa has been a leader in providing quality early childhood education (ECE) for children/tamariki and their families/whānau. ECE represents a diverse set of services for children under the age of five. A unique feature of
Phillips, J   +11 more
core   +1 more source

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