Results 161 to 170 of about 1,392,284 (290)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

"Cancer" as a meaningful manifestation of lifestyle disharmony: Exploring oncology nursing for the prevention and early detection of cancer in the context of Margaret Newman's theory of health as expanding consciousness. [PDF]

Asia Pac J Oncol Nurs, 2022
Mitsugi M, Endo E.
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Signatures Beyond Oncogenic Mutations in Cell-Free DNA Sequencing for Non-Invasive, Early Detection of Cancer. [PDF]

Front Genet, 2021
De S.
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Artificial Intelligence in Radiology: Advancing Precision, Accuracy, and Early Detection in Cancer Diagnosis. [PDF]

Cureus
Gurjar P, Mayana SK, Reddy Annadevula SK, Singh B, Sambhav K, Shah SB.   +5 more
europepmc   +1 more source

C. elegans-based chemosensation strategy for the early detection of cancer metabolites in urine samples. [PDF]

Sci Rep, 2021
Lanza E, Di Rocco M, Schwartz S, Caprini D, Milanetti E, Ferrarese G, Lonardo MT, Pannone L, Ruocco G, Martinelli S, Folli V.   +10 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Incident anaemia as a marker of cancer and all-cause mortality: evidence from 380 114 adults in the population-based Stockholm Early Detection of Cancer Study (STEADY-CAN) cohort. [PDF]

BMJ Oncol
Nemlander E, Abedi E, Hasselström J, Ljungman P, Rosenblad A, Carlsson A.   +5 more
europepmc   +1 more source

Early detection breast cancer: role of circulating plasma miRNA-21 expression as a potential screening biomarker [PDF]

Turk J Med Sci, 2021
Diansyah MN, Prayogo AA, Sedana MP, Savitri M, Zaky Romadhon P, Niken Ayu Amrita P, Yasmin Wijaya A, May Hendrata W, Yudho Bintoro U.   +8 more
europepmc   +1 more source