Results 141 to 150 of about 813,162 (218)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

The chemotactic response of Caenorhabditis elegans represents a promising tool for the early detection of cancer. [PDF]

Discov Oncol
Kaiglová A, Hockicková P, Bárdyová Z, Reháková R, Melnikov K, Kucharíková S.   +5 more
europepmc   +1 more source

Prediction of occult tumor progression via platelet RNAs in a mouse melanoma model: a potential new platform for early detection of cancer. [PDF]

J Transl Med, 2022
Yin Y, Jiang R, Shen M, Li Z, Yan N, Feng J, Jiang H, Lv J, Shi L, Wang L, Liu X, Zhang K, Chen D.   +12 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Early Detection of Cancer and Precancerous Lesions in Persons With HIV Through a Comprehensive Cancer Screening Protocol. [PDF]

Clin Infect Dis
Gutiérrez F, López L, Galera C, Tiraboschi JM, Portu J, García-Fraile L, García Del Toro M, Bernal E, Rivero A, García-Abellán J, Flores J, González-Cordón A, Martínez O, Bravo J, Rosado D, Montero M, Sirera G, Torralba M, Galindo MJ, Macías J, Gónzalez-Cuello I, Boix V, Vivancos MJ, Dios P, Blanco JR, Padilla S, Fernández-González M, Gutiérrez-Ortiz de la Tabla A, Martínez E, Masiá M, IMPAC-Neo Study Group.   +30 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Advances in micro-/nanorobots for cancer diagnosis and treatment: propulsion mechanisms, early detection, and cancer therapy. [PDF]

Front Chem
Fu B, Luo D, Li C, Feng Y, Liang W.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Colocalization of Cancer-Associated Biomarkers on Single Extracellular Vesicles for Early Detection of Cancer. [PDF]

J Mol Diagn
Salem DP, Bortolin LT, Gusenleitner D, Grosha J, Zabroski IO, Biette KM, Banerjee S, Sedlak CR, Byrne DM, Hamzeh BF, King MS, Cuoco LT, Santos-Heiman T, Barcaskey GN, Yang KS, Duff PA, Winn-Deen ES, Guettouche T, Mattoon DR, Huang EK, Schekman RW, Couvillon AD, Sedlak JC.   +22 more
europepmc   +1 more source