Results 121 to 130 of about 813,162 (218)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Multiplex Digital PCR Assay Targeting DNA Methylation for Early Detection of Cancer. [PDF]

Methods Mol Biol
Cannon V, Wright JH, Yeung CCS, Grady WM, Yu M.   +4 more
europepmc   +1 more source

Personalized statistical learning algorithms to improve the early detection of cancer using longitudinal biomarkers. [PDF]

Cancer Biomark, 2022
Tayob N, Feng Z.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Artificial Intelligence in Radiology: Advancing Precision, Accuracy, and Early Detection in Cancer Diagnosis. [PDF]

Cureus
Gurjar P, Mayana SK, Reddy Annadevula SK, Singh B, Sambhav K, Shah SB.   +5 more
europepmc   +1 more source

"Cancer" as a meaningful manifestation of lifestyle disharmony: Exploring oncology nursing for the prevention and early detection of cancer in the context of Margaret Newman's theory of health as expanding consciousness. [PDF]

Asia Pac J Oncol Nurs, 2022
Mitsugi M, Endo E.
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

DNA remnants in red blood cells enable early detection of cancer. [PDF]

Cell Res
Sun H, Yao X, Jiao Y, Kong X, Han Y, Li Y, Ge J, Cao Y, Lu H, Wang P, Xu Y, Li J, Ding K, Gao X.   +13 more
europepmc   +1 more source

C. elegans-based chemosensation strategy for the early detection of cancer metabolites in urine samples. [PDF]

Sci Rep, 2021
Lanza E, Di Rocco M, Schwartz S, Caprini D, Milanetti E, Ferrarese G, Lonardo MT, Pannone L, Ruocco G, Martinelli S, Folli V.   +10 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source