Results 131 to 140 of about 1,392,284 (290)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Integrative analysis of blood biomarkers and clinical variables improves early detection of aggressive prostate cancer

Scientific Reports
Aggressive prostate cancer (PC) represents a significant health concern. Conventional screening methods, primarily based on prostate-specific antigen (PSA) levels, lack specificity, leading to an urgent need for more accurate diagnostic tools. This study
Olga Lazareva, Anja Riediger, Oliver Stegle, Holger Sültmann, Markus Hohenfellner, Magdalena Görtz   +5 more
doaj   +1 more source

What Is Differences between Medical Imaging Modalities for Assessment of the Breast [PDF]

Breast cancer is the most common female cancer with more than 45,000 cases diagnosed per annum in the UK. Early detection of breast cancer is associated with improved survival. There are several imaging modalities for assessment of the breast.
بهروزكيا, ژاله, حدادی, غلامحسن, رفاهی, سهیلا   +2 more
core  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Early detection of pancreatic cancer

World Journal of Clinical Cases
The diagnosis of pancreatic cancer associates an appalling significance. Detection of preinvasive stage of pancreatic cancer will ameliorate the survival of this deadly disease. Premalignant lesions such as Intraductal Papillary Mucinous Neoplasms or Mucinous Cystic Neoplasms of the pancreas are detectable on imaging exams and this permits their ...
openaire   +2 more sources

Exploring Circulating Tumor DNA (CtDNA) and Its Role in Early Detection of Cancer: A Systematic Review. [PDF]

Cureus, 2023
Bittla P, Kaur S, Sojitra V, Zahra A, Hutchinson J, Folawemi O, Khan S.   +6 more
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Impact of early detection on cancer curability: A modified Delphi panel study. [PDF]

PLoS One, 2022
Schwartzberg L, Broder MS, Ailawadhi S, Beltran H, Blakely LJ, Budd GT, Carr L, Cecchini M, Cobb P, Kansal A, Kim A, Monk BJ, Wong DJ, Campos C, Yermilov I.   +14 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Evaluation of Usability and User Experience of Oncodoc 's M-Health Application for Early Detection of Cancer. [PDF]

Asian Pac J Cancer Prev, 2022
Wulandari R, Pangarsa EA, Andono PN, Rachmani E, Sidiq M, Setyowati M, Waluyo DE.   +6 more
europepmc   +1 more source