Results 111 to 120 of about 1,392,284 (290)

Mutation of the peptide-regulated transcription factor ComR for amidated peptide specificity and heterologous function in Lactiplantibacillus plantarum WCFS1

Microbiology Spectrum
There is a growing interest in the use of probiotic bacteria as biosensors for the detection of disease. However, there is a lack of bacterial receptors developed for specific disease biomarkers.
Michael Brasino, Eli Wagnell, E. Sila Ozdemir, Srivathsan Ranganathan, Justin Merritt   +4 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Barriers and contributions of rural community health workers in enabling cancer early detection and subsequent care in India: a qualitative study

BMC Public Health
Background The cancer burden in India is escalating, with rural regions facing the greatest challenges in access to early detection and treatment. Community Health Workers (CHWs), such as Accredited Social Health Activists (ASHAs), Village Health Nurses (
Sathishrajaa Palaniraja, Katayoun Taghavi, Ishu Kataria, Kunal Oswal, Nandimandalam Venkata Vani, Asiya Ansari Liji, Hardika Parekh, Rita Isaac, Moni Kuriakose, Rajaraman Swaminathan, Rohit Rebello, Arnie Purushotham, Partha Basu, Richard Sullivan, Arunah Chandran   +14 more
doaj   +1 more source

Systemic treatments for women with breast cancer: outcome with relation to screening for the disease [PDF]

, 2017
Early detection and proper care of breast cancer are currently the best available approaches to the treatment of patients with the disease. In countries with a breast cancer screening programme, there has been a demonstrated reduction in breast cancer ...
Colleoni, M., Domenighetti, G., Gelber, R. D., Goldhirsch, A.   +3 more
core  

Biomarkers for Early Detection of Cancer: Molecular Aspects. [PDF]

Int J Mol Sci, 2023
Tappia PS, Ramjiawan B.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Implementation of an electronic health information system using DHIS2 tracker to manage and evaluate the National cervical screening programme in Bangladesh

BMC Public Health
Background The cervical screening programme in Bangladesh upgraded its electronic health information system (e-HIS) in 2019 using DHIS2 tracker application. The upgraded e-HIS collects individual level data and has useful functionalities like sending SMS
Ashrafun Nessa, Shekh Md Nazim Uddin, Eric Lucas, Pradip Nag, Sathishrajaa Palaniraja, Maryluz Rol, Md. Abdus Salam Khan, Muhammad Abdul Hannan Khan, Shirin Akter Begum, Romena Afroz, Noor E Ferdous, Richard Muwonge, Partha Basu   +12 more
doaj   +1 more source

Mucins as Potential Biomarkers for Early Detection of Cancer. [PDF]

Cancers (Basel), 2023
Gautam SK, Khan P, Natarajan G, Atri P, Aithal A, Ganti AK, Batra SK, Nasser MW, Jain M.   +8 more
europepmc   +1 more source