Results 91 to 100 of about 5,988,743 (297)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Een archeologisch bureauonderzoek (BO)

, 2022
In opdracht van RPS- Advies en Ingenieursbureau heeft EARTH Integrated Archaeology in juli 2021 een archeologisch bureauonderzoek uitgevoerd in plangebied Sourethweg, gemeente Heerlen.
Rumping, MSc S (EARTH Integrated Archaeology), Moor, Dr. J de (EARTH Integrated Archaeology), Grothe, MSc K (EARTH Integrated Archaeology), K Grothe, J de Moor, S Rumping   +5 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Associations between the 2022 global mpox outbreak and multifaceted factors: A multi-geographical retrospective study

One Health
Unlike prior travel-related mpox cases, the 2022 outbreak of mpox virus (MPXV) clade IIb outside endemic regions posed a significant global health threat.
Yuxi Ge, Yifei Wang, Ziqin Zhou, Zhirui Zhang, Yunyu Tian, Yun Feng, Peiyi Wu, Yuxin Wang, Ziyan Liu, Bingying Li, Zengmiao Wang   +10 more
doaj   +1 more source

Extreme Drought Events over Brazil from 2011 to 2019

Atmosphere, 2019
Drought-related disasters are among the natural disasters that are able to cause large economic and social losses. In recent years, droughts have affected different regions of Brazil, impacting water, food, and energy security. In this study, we used the
Ana Paula M. A. Cunha, Marcelo Zeri, Karinne Deusdará Leal, Lidiane Costa, Luz Adriana Cuartas, José Antônio Marengo, Javier Tomasella, Rita Marcia Vieira, Alexandre Augusto Barbosa, Christopher Cunningham, João Victor Cal Garcia, Elisangela Broedel, Regina Alvalá, Germano Ribeiro-Neto   +13 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Global-scale water circulation in the Earth's mantle: Implications for the mantle water budget in the early Earth

, 2017
© 2017 Elsevier B.V. We investigate the influence of the mantle water content in the early Earth on that in the present mantle using numerical convection simulations that include three processes for redistribution of water: dehydration, partitioning of ...
Marc W. Spiegelman, Nakagawa, Takashi, Takashi Nakagawa, Spiegelman, Marc W.   +3 more
core   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Earth-prints Archivio Aperto

, 2005
Geophysics Open archive. Free access to worldwide scientists during search and submission process. Earth-Prints is an open archive created and maintained by Istituto Nazionale di Geofisica e Vulcanologia with the collaboration of Programma Nazionale ...
Chiodetti, A. G.
core   +1 more source

Widespread Impact‐Induced Crustal Permeability on the Early Earth

AGU Advances
The early Earth (i.e., Archean and Hadean Eons, 2.5–4.0 and 4.0–4.5 Ga, respectively) experienced frequent cosmic bombardment. Impacts have been shown to stimulate crustal alteration, for instance via hydrothermal systems active for up to millions of ...
A. M. Alexander, S. Marchi, B. C. Johnson   +2 more
doaj   +1 more source