Results 71 to 80 of about 5,988,743 (297)

Phanerozoic seawater Mg/Ca variations driven by supercontinent cycles

Nature Communications
Seawater Mg/Ca has oscillated markedly over the Phanerozoic, closely associated with secular variations in sedimentation, icehouse-greenhouse fluctuations, and the evolution of calcifying invertebrates.
Pan Zhang, Mark A. Kendrick, Yigui Han, Long Ma, Kang-Jun Huang   +4 more
doaj   +1 more source

Hydrogeochemical impacts of coal mining on multi-aquifer systems: A case study in the Linhuan Mining District, China

Ecotoxicology and Environmental Safety
Coal mining activities present significant threats to groundwater quality in multi-aquifer systems. This study examines the hydrogeochemical processes and evolutionary pathways induced by mining operations in the Linhuan mining district, located in the ...
Qiding Ju, Youbiao Hu, Qimeng Liu
doaj   +1 more source

Palaeobotany: The Rise of the Earth’s Early Forests [PDF]

Current Biology, 2019
Rare fossil forests are the best evidence for the ecology of the pioneering large land plants that transformed the Earth system and the terrestrial environment. A new study reveals a spectacular, remarkably extensive early fossil forest in China and sheds light on the evolution of key rooting systems.
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Tracing Continental Basalt Sources and Mantle Processes Using Fe Stable Isotopes

Geochemistry, Geophysics, Geosystems
Iron (Fe) isotopes have emerged as powerful tracers of mantle source heterogeneity and melting processes, yet the mechanisms producing heavy Fe isotope signatures (high δ57Fe values) in intraplate basalts remain debated. Competing interpretations include
Yi‐Shan Cheng, Jian‐Qiang Liu, Li‐Hui Chen, Xun Yu, Gang Zeng, Xiao‐Jun Wang, Zhao‐Yang He, Jian Zhao, Frances M. Deegan, Valentin R. Troll, Hong‐Fu Zhang   +10 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Prebiotic Phosphorylation Reactions on the Early Earth

Challenges, 2014
Phosphorus (P) is an essential element for life. It occurs in living beings in the form of phosphate, which is ubiquitous in biochemistry, chiefly in the form of C-O-P (carbon, oxygen and phosphorus), C-P, or P-O-P linkages to form life. Within prebiotic
Maheen Gull
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source