Results 51 to 60 of about 136,179 (257)
Phanerozoic seawater Mg/Ca variations driven by supercontinent cycles
Nature CommunicationsSeawater Mg/Ca has oscillated markedly over the Phanerozoic, closely associated with secular variations in sedimentation, icehouse-greenhouse fluctuations, and the evolution of calcifying invertebrates.
Pan Zhang +4 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Prebiotic Phosphorylation Reactions on the Early Earth
Challenges, 2014 Phosphorus (P) is an essential element for life. It occurs in living beings in the form of phosphate, which is ubiquitous in biochemistry, chiefly in the form of C-O-P (carbon, oxygen and phosphorus), C-P, or P-O-P linkages to form life. Within prebiotic
Maheen Gull
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Palaeobotany: The Rise of the Earth’s Early Forests [PDF]
Current Biology, 2019 Rare fossil forests are the best evidence for the ecology of the pioneering large land plants that transformed the Earth system and the terrestrial environment. A new study reveals a spectacular, remarkably extensive early fossil forest in China and sheds light on the evolution of key rooting systems.
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
BMC Evolutionary Biology, 2018 Background Extended parental care is a complex reproductive strategy in which progenitors actively look after their offspring up to – or beyond – the first juvenile stage in order to maximize their fitness.
Dongjing Fu +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
THE SUN AND THE BIOSPHERE: THE PARADOXES OF 4 BILLION YEARS OF COEXISTENCE
Radio Physics and Radio Astronomy, 2017 Purpose: The paper discusses the influence of the early Sun and the solar system parameters on the paleomagnetic field and the development of life on Earth.
M. V. Ragulskaya, V. N. Obridko
doaj +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source