Results 61 to 70 of about 5,988,743 (297)

Prolonged super-orogens during Gondwana assembly contributed to the formation of a habitable Earth: Insights from big data

China Geology
Since the initiation of plate tectonics on Earth, the evolution of tectonic regime and supercontinent cycles (Nuna, Rodinia and Pangea) have been the first order factors that contributed to Earth surficial environmental changes and thus development of ...
Peng-yuan Cui, Jin-long Yao, Guo-chun Zhao, Yi-gui Han, Qian Liu, Dong-hai Zhang, Hang Yang   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

EARTH Integrated Archaeology Rapporten 1162

, 2022
In opdracht van Aeres Milieu heeft EARTH Integrated Archaeology B.V. in november 2020 een verkennend booronderzoek (IVO-O) uitgevoerd in een plangebied in Almere Stad aan de Landdrostdreef. Aanleiding voor het onderzoek is de geplande herinrichting van
Rumping, MSc S. (EARTH Integrated Archaeology), Moor, Dr. J.J.W. de (EARTH Integrated Archaeology), J.J.W. de Moor, S. Rumping   +3 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Declaration of the Earth Observation Summit [PDF]

, 2003
This single page document is a declaration of the participants of the Earth Observation Summit held in Washington DC, adopted on July 31, 2003. An affirmation for the need for timely, quality, long-term, global information as a basis for sound decision ...
[Earth Observation Summit]
core  

The Wilson Cycle of the North Altyn Ocean: A Record of Subduction Initiation, Slab Rollback, and Final Closure

Geochemistry, Geophysics, Geosystems
The North Altyn ophiolitic belt was formed by the subduction–closure of the Altyn segment of the Proto–Tethys Ocean and recorded the accretion of Tarim to northern Gondwana, but the timing of initial subduction and detailed tectonic transition processes ...
Long Chen, Jinlong Yao, Guochun Zhao, Yigui Han, Qian Liu, Donghai Zhang, Xijun Zhao, Hang Yang, Wei Li   +8 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Early childhood flexibility practices and patterns: report 2014 [PDF]

, 2014
The Early childhood flexibility practices and patterns report highlights recommendations and future directions for early childhood education and care (ECEC) services in providing flexible arrangements for families and local communities.
Early Childhood Australia
core  

EARTH Integrated Archaeology Rapporten 148

, 2021
In juni 2020 heeft EARTH Integrated Archaeology een archeologisch bureauonderzoek (BO) uitgevoerd binnen een plangebied te Nieuw-Lekkerland, gemeente Molenlanden. Het gehele plangebied is opgedeeld in waardes archeologie 2, 4 en 5.
Vanderhoeven, Drs. T. (EARTH Integrated Archaeology), Grothe, MSc K. (EARTH Integrated Archaeology), K. Grothe, T. Vanderhoeven   +3 more
core   +1 more source