Results 151 to 160 of about 11,648,449 (278)

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Evolution of Sepsis Management in the Emergency Department: From Early Goal-Directed Therapy to Personalized Resuscitation. [PDF]

Cureus
Mansoor NM, Ghassan L, Haider Ali AM, AlShehabi H, Mohamed F.   +4 more
europepmc   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

A Framework for Goal Generation and Management

, 2010
Goal-directed behaviour is often viewed as an essential char- acteristic of an intelligent system, but mechanisms to generate and manage goals are often overlooked.
Hanheide, Marc,, Göbelbecker, Moritz,, Kruijff, Geert-Jan,, Wyatt, Jeremy,, Sjöö, Kristoffer,, Zender, Hendrik,, Hawes, Nick,, Brenner, Michael,, Jensfelt, Patric,, Aydemir, Alper,   +9 more
core   +1 more source

What comes after the Early Goal Directed Therapy for sepsis era? [PDF]

J Thorac Dis, 2017
Edriss H.
europepmc   +1 more source

A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation

Advanced Science, EarlyView.
A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang   +5 more
wiley   +1 more source

Efficacy of Early Goal-Directed Therapy in Septic Shock Management: A Systematic Review. [PDF]

Cureus
Acharya P, Virani S, Afreen S, Perthiani A, Sangster E, Lanka N, Malasevskaia I.   +6 more
europepmc   +1 more source

Value of Central Venous to Arterial CO₂ Difference after Early Goal-directed Therapy in Septic Shock Patients. [PDF]

Indian J Crit Care Med, 2019
Araujo DT, Felice VB, Meregalli AF, Friedman G.   +3 more
europepmc   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Heterogeneity in the Effect of Early Goal-Directed Therapy for Septic Shock: A Secondary Analysis of Two Multicenter International Trials. [PDF]

Crit Care Med
Shah FA, Talisa VB, Chang CH, Triantafyllou S, Tang L, Mayr FB, Higgins AM, Peake SL, Mouncey P, Harrison DA, DeMerle KM, Kennedy JN, Cooper GF, Bellomo R, Rowan K, Yealy DM, Seymour CW, Angus DC, Yende SP.   +18 more
europepmc   +1 more source