Results 121 to 130 of about 5,125,891 (242)

Early Orndorff Papers, 1868-1942

open access: yes
Papers, 1868-1942, of the King and Orndorff families of Van Buren Furnace, Shenandoah County, Va. The collection includes papers, 1891-1942, of Early Orndorff, documents in German of a maternal ancestor, Emily Wilde, who came to America in 1877 and ...
Rochling, G.H., Orndorff, Early
core  

Survival of Homo Sapiens –A Retrospect Analysis

open access: yes, 2020
Our understanding of human evolution is in the form of evidence of available fossil remains based on discoveries made in the last two hundred years Most of these discoveries are incidental in nature and they do not have the correct serialization and ...
Reya Santra, Harashawaradhana
core  

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

open access: yesFEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park   +8 more
wiley   +1 more source

Psychiatric Dispositive and Production of Killable Subjects in Brazil between the Late 19th and Early 20th Centuries

open access: yesDilemas: Revista de Estudos de Conflito e Controle Social, 2019
From Michel Foucault’s contributions (and his concepts of biopower and dispositive) and Giorgio Agamben (Homo Sacer) it is discussed how deaths were produced by the psychiatry in Brazil of the late nineteenth and early twentieth century.
Silvio de Azevedo Soares   +1 more
doaj  

Testing the taxonomy of Dmanisi hominin fossils through dental crown area.

open access: yesPLoS ONE
The Dmanisi paleoanthropological assemblage from Georgia is among the most debated collections of hominin fossils due to its early age and extreme morphological diversity relative to other Homo assemblages.
Victor Nery   +3 more
doaj   +1 more source

The bears from Dmanisi and the first dispersal of early Homo out of Africa. [PDF]

open access: yesSci Rep, 2019
Medin T   +8 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

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