Results 111 to 120 of about 292,316 (287)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
EVOLUTION OF RELIGIOUS CAPACITY IN THE GENUS HOMO: COGNITIVE TIME SEQUENCE
Zygon, 2018 Intrigued by the possible paths that the evolution of religious capacity may have taken, the authors identify a series of six major building blocks that form a foundation for religious capacity in genus Homo.
doaj +2 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Arheologia Moldovei, 2016 The mismatch between the human paleoanthropological ‘tree’ and the paleo-cognitive ‘ladder’ has been recently attributed to epistemological biases affecting the mainstream narratives on cognitive evolution.
Mircea Anghelinu
doaj +1 more source
Endocranial ontogeny and evolution in early <i>Homo sapiens</i>: The evidence from Herto, Ethiopia. [PDF]
Proc Natl Acad Sci U S A, 2022 Zollikofer CPE +6 more
europepmc +1 more source
A contribution to the question of early Homo in southern Africa : researches into dating, taxonomy and phylogeny reconstruction [PDF]
, 2017 The origin of genus Homo is a core problem in contemporary palaeoanthropology. Most research in early hominid studies has hitherto focussed on the bearing of East African hominids on this problem.
Curnoe, Darren K
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
, 2012 Many hominin species are best physically represented and understood by the sum of their dental morphologies. Generally, taxonomic affinities and evolutionary trends in development (ontogeny) and morphology (phylogeny) can be deduced from dental analyses.
Tausch, Jeremy
core
Quaternary Environments and HumansDursunlu, located in the Ilgın Basin (south-western Türkiye), represents one of the most prolific sites to explore early human occupations in Anatolia. This paper describes the lacustrine fish assemblage from this site during the Early Pleistocene (Günz ...
Àngel Blanco-Lapaz +3 more
doaj +1 more source