Results 91 to 100 of about 8,201,974 (327)

The hand of Homo naledi [PDF]

, 2015
A nearly complete right hand of an adult hominin was recovered from the Rising Star cave system, South Africa. Based on associated hominin material, the bones of this hand are attributed to Homo naledi.
AB Falsetti, AS Deane, AS Deane, AS Deane, BG Richmond, C Rolian, C Rolian, CM Orr, CO Lovejoy, CV Ward, CV Ward, CV Ward, CV Ward, CV Ward, D Lordkipanidze, DE Lieberman, DJ Green, DM Alba, F Weidenreich, H Preuschoft, HM McHenry, JE Mosimann, JR Napier, JR Napier, JT Stern Jr., KD Hunt, LR Berger, LR Berger, ME Bush, MM Shrewsbury, MW Markze, MW Marzke, MW Marzke, MW Marzke, MW Marzke, MW Marzke, MW Tocheri, MW Tocheri, MW Tocheri, MW Tocheri, MW Tocheri, NH Nguyen, RH Tuttle, RL Susman, S Almécija, SL Smith, TL Kivell, WEH Harcourt-Smith, WL Jungers, WL Jungers   +49 more
core   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Did climate change make Homo sapiens innovative, and if yes, how? Debated perspectives on the African Pleistocene record

Quaternary Science Advances
Our enhanced capacity to innovate is a key feature that sets Homo sapiens apart as a species. The Middle Stone Age archaeological record of Pleistocene Africa documents the emergence and elaboration of this capacity, and its relationship to changes in ...
Jayne Wilkins, Benjamin J. Schoville
doaj   +1 more source

Long non-coding RNA SENCR is a positive regulator of ETV2 [PDF]

, 2017
Department of Biological SciencesAlthough long non-coding RNAs (lncRNAs) have emerged as novel regulator of cell fate and gene expression, the regulation of vascular specific transcription factor by lncRNA in generation of induced endothelial cells ...
Jeong, Yujin
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Exploring the Locus of Anthropos in Market Ecology: When the Homo Politicus Converses with the Homo Economicus [PDF]

, 2014
The dilemma of the anthropos confuses him as to the advantage of the market to his existence. The market anthropos is seen as homo economicus, a self-interested, utility-maximizing individual.
Macaraan, Willard Enrique
core   +1 more source