Results 101 to 110 of about 5,125,891 (242)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

open access: yesFEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança   +2 more
wiley   +1 more source

Dispersal of Homo sapiens around the Indian Ocean rim: a geometric morphometric study of craniofacial diversity. [PDF]

open access: yes, 2007
This thesis explores craniofacial diversity found in Homo sapiens around the Indian Ocean rim. Three dimensional landmark data, taken directly from the craniofacial skeleton, are examined in relation to the hypothesised southern dispersal route taken by ...
Buck, Trudi Jane
core  

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

Para além do homo economicus as contribuições da economia comportamental e institucional para a compreensão do comportamento econômico humano [PDF]

open access: yes, 2013
TCC (Graduação) - Universidade Federal de Santa Catarina. Centro Socioeconômico. Curso de Graduação em Ciências Econômicas.O comportamento econômico está consolidado na Economia sobre a forma do homo economicus, um modelo que concebe o indivíduo com ...
Figueiredo, Marcus Vinícius Pansera
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Bibliographica (Issue 2)

open access: yes, 2006
The second issue of Bibliographica (Spring 2005) featured Julie Russell-Steuart introducing her Caveworks Press [blacked out due to absence of permission for online archiving], a few thoughts spurred by Kat Ran Press's ephemera club, and an overview of ...
Homo, Kira, Russell, John
core   +3 more sources

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

open access: yesFEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui   +4 more
wiley   +1 more source

Special Issue: Australopithecus sediba --- The Skull of Australopithecus sediba

open access: yesPaleoAnthropology, 2018
Australopithecus sediba presents a mosaic of both australopith-like and Homo-like characters. The preliminary ac-count of the skull of Au. sediba provided in Berger et al.
Darryl J. De Ruiter   +5 more
doaj  

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