Results 101 to 110 of about 8,201,974 (327)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Ecological limiting factors of early hominins in western Eurasia

One Health & Risk Management, 2023
Introduction. Early hominin (Homo ex. gr. erectus) dispersals from Africa into western Eurasia took place during the Early Pleistocene. Evidence points to the presence of humans in Western Europe, specifically Spain, around 1.1-1.2 Ma and in the ...
Roman CROITOR
doaj  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Homo erectus adapted to steppe-desert climate extremes one million years ago

Communications Earth & Environment
Questions about when early members of the genus Homo adapted to extreme environments like deserts and rainforests have traditionally focused on Homo sapiens.
Julio Mercader, Pamela Akuku, Nicole Boivin, Alfredo Camacho, Tristan Carter, Siobhán Clarke, Arturo Cueva Temprana, Julien Favreau, Jennifer Galloway, Raquel Hernando, Haiping Huang, Stephen Hubbard, Jed O. Kaplan, Steve Larter, Stephen Magohe, Abdallah Mohamed, Aloyce Mwambwiga, Ayoola Oladele, Michael Petraglia, Patrick Roberts, Palmira Saladié, Abel Shikoni, Renzo Silva, María Soto, Dominica Stricklin, Degsew Z. Mekonnen, Wenran Zhao, Paul Durkin   +27 more
doaj   +1 more source

Two more Uhlenbeck memories (and more Basque parallels)

Fontes Linguae Vasconum, 1995
I. Prefix a- denoting persons and the possible existence of an ergative are grammatical features that Etruscan has in common with Basque. II. The etymology of Basque burdin, etc. "iron" is still uncertain (probably a loan from Asia). III. There is
W. Wilfried Schuhmacher
doaj   +1 more source

Dental development in Australopithecus and early Homo [PDF]

Nature, 1986
Human ontogeny requires nearly twice the time as that of living apes1. This extended period of maturation is usually regarded as a significant evolutionary advance enhancing the importance of learning1–5. Mann6 suggested that alteration of the timing of growth and development occurred very early in hominid evolution, using evidence based on a human ...
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Genetic analysis of lice supports direct contact between modern and archaic humans.

PLoS Biology, 2004
Parasites can be used as unique markers to investigate host evolutionary history, independent of host data. Here we show that modern human head lice, Pediculus humanus, are composed of two ancient lineages, whose origin predates modern Homo sapiens by an
David L Reed, Vincent S Smith, Shaless L Hammond, Alan R Rogers, Dale H Clayton   +4 more
doaj   +1 more source