Results 61 to 70 of about 19,801,094 (386)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Unveiling the early evolution of black corals

Communications Biology
Black corals, primarily deep-sea cnidarians (Anthozoa: Antipatharia), are inferred to have originated either in the Ediacaran or Cambrian based on molecular clock estimates.
Wenjing Hao, Jian Han, Andrzej Baliński, Mercer R. Brugler, Deng Wang, Xin Wang, Bernhard Ruthensteiner, Tsuyoshi Komiya, Jie Sun, Yuanyuan Yong, Xikun Song   +10 more
doaj   +1 more source

Spatial dynamics of homochiralization [PDF]

, 2005
The emergence and spreading of chirality on the early Earth is considered by studying a set of reaction-diffusion equations based on a polymerization model.
Brandenburg, Axel, Multamaki, Tuomas
core   +2 more sources

Postbiotics and Their Potential Applications in Early Life Nutrition and Beyond

International Journal of Molecular Sciences, 2019
Postbiotics are functional bioactive compounds, generated in a matrix during fermentation, which may be used to promote health. The term postbiotics can be regarded as an umbrella term for all synonyms and related terms of these microbial fermentation ...
C. A. Wegh, Sharon Y. Geerlings, J. Knol, G. Roeselers, C. Belzer   +4 more
semanticscholar   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Paleoenvironmental reconstruction of the Middle Ordovician Majiagou Formation in the northeastern Ordos Basin and its effect on organic matter enrichment

Scientific Reports
The alteration of paleoenvironment is a crucial factor influencing the variations in hydrocarbon-forming organisms and the preservation of organic matter.
Yiran Wang, Xiaofeng Wang, Wenhui Liu, Tao Zhang, Dongdong Zhang   +4 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Notes on the Life Histories of \u3ci\u3eAcrosternum Hilare\u3c/i\u3e and \u3ci\u3eCosmopepla Bimaculata\u3c/i\u3e (Heteroptera: Pentatomidae) in Southern Illinois [PDF]

, 2018
The life histories of Acrosternum hilare and Cosmopepla bimaculata were studied in southern Illinois from May 1972 to September 1974 and from September 1992 to June 1995.
McPherson, J. E, Tecic, D. L
core   +2 more sources

Early life stress alters transcriptomic patterning across reward circuitry in male and female mice

Nature Communications, 2019
Abuse, neglect, and other forms of early life stress (ELS) significantly increase risk for psychiatric disorders including depression. In this study, we show that ELS in a postnatal sensitive period increases sensitivity to adult stress in female mice ...
C. Peña, Milo R. Smith, Aarthi Ramakrishnan, H. Cates, R. Bagot, Hope G. Kronman, Bhakti Patel, Austin B. Chang, Immanuel Purushothaman, J. Dudley, H. Morishita, Li Shen, E. Nestler   +12 more
semanticscholar   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source