Results 71 to 80 of about 13,584,933 (301)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The effects of shocks in early life mortality on later life expectancy and mortality compression: A cohort analysis [PDF]
I study how shocks in cohort-level early life conditions, as represented by deviations from trend in mortality before age 5, affect later mortality. I use data for six European countries and find that shocks that increase infant mortality decrease later ...
Mikko Myrskylä
core
Early childhood flexibility practices and patterns [PDF]
, 2014 Executive summary The early childhood flexibility practices and patterns report highlights recommendations and future directions for early childhood education and care (ECEC) services in providing flexible arrangements for families and local ...
core
Board Chairs’ Early-Life Experience and Tax Avoidance
, 2023 Understanding tax avoidance becomes a matter of significant interest as it is not just a financial problem but also an organizational ethical and integrity issue.
Yao, D +7 more
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
UK Early Life Cohort Feasibility Study: Age 9-10 months Sweep, 2023-2024
copyright UK Data Service and data collection copyright owner.The overarching aim of the Early Life Cohort Feasibility Study (ELC-FS) was to explore the feasibility of a new birth cohort study in the UK that would paint a nationally representative ...
University of London, Institute of Education, Centre for Longitudinal Studies
core +2 more sources
Geophysical Research LettersThe absence of reliable paleomagnetic constraints from the Lhasa Block has led to alternative interpretations of its late Paleozoic position and timing of rifting from Gondwana, reflecting uncertainties in early Neo‐Tethyan paleogeography.
Longyun Xing +12 more
doaj +1 more source