Results 91 to 100 of about 13,943,232 (281)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Early Life Stress and Gut Microbiome Dysbiosis: A Narrative Review

Stresses
Background: Exposure to early life stress significantly increases the risk of psychopathology later in life. However, the impact of early life stress on the gut microbiome and its potential role in mental health outcomes remains insufficiently understood.
Alejandro Borrego-Ruiz, Juan J. Borrego
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Cortisol diurnal rhythm and stress reactivity in male adolescents with early-onset or adolescence-onset conduct disorder [PDF]

, 2008
Background: Previous studies have reported lower basal cortisol levels and reduced cortisol responses to stress in children and adolescents with conduct disorder (CD). It is not known whether these findings are specific to early-onset CD.
Stephanie H.M. van Goozen, Sarah J. Stollery, Gardiner, Julian, van Goozen, Stephanie HM, van Goozen, Stephanie H.M., Van Goozen, Stephanie Helena Maria, Graeme Fairchild, Stollery, Sarah J., Goodyer, Ian M, Herbert, Joe, Stollery, Sarah J, Brown, Jamie, Goodyer, Ian M., Goodyer, Ian M., Ian M. Goodyer, Julian Gardiner, Stollery, Sarah J.., Joe Herbert, Jamie Brown, Fairchild, Graeme   +19 more
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Long-term effect of early-life stress from earthquake exposure on working memory in adulthood

, 2015
Na Li,1-3* Yumei Wang,1-3* Xiaochuan Zhao,1-3 Yuanyuan Gao,1-3 Mei Song,1-3 Lulu Yu,1-3 Lan Wang,1-3 Ning Li,1-3 Qianqian Chen,1-3 Yunpeng Li,1-3 Jiajia Cai,1-3 Xueyi Wang1-31Department of Psychiatry, The ...
Yu L, Chen Q, Li Y, Song M, Gao Y, Cai J, Wang X, Wang Y, Li N, Zhao X, Wang L   +10 more
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Perinatal programming of neuroendocrine mechanisms connecting feeding behavior and stress

Frontiers in Neuroscience, 2013
Feeding behavior is closely regulated by neuroendocrine mechanisms that can be influenced by stressful life events. However, the feeding response to stress varies among individuals with some increasing and others decreasing food intake after stress.
Sarah J Spencer
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

4. Early Life Care Konferenz

Als Zusammenfassung der diesjährigen Konferenzinhalte zum Leitthema „Ressourcen – Grundlagen für einen guten Start ins Leben“ dürfen wir Ihnen diesen Abstractband übermitteln.
Paracelsus Medizinische Universität. Institut für Early Life Care
core   +1 more source