Methamphetamine and the hypothalamic-pituitary-adrenal axis [PDF]
Frontiers in Neuroscience, 2015 Psychostimulants such as methamphetamine (MA) induce significant alterations in the function of the hypothalamic-pituitary-adrenal (HPA) axis. These changes in HPA axis function are associated with altered stress-related behaviors and might contribute ...
Damian Gabriel Zuloaga +2 more
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Hypothalamic–pituitary–adrenal axis activity and neurotrophic factors in drug-naive children and adolescents with attention-deficit/hyperactivity disorder [PDF]
Frontiers in PsychiatryBackgroundAttention deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with a complex and not fully understood etiology. Increasing evidence suggests that neurotrophic factors involved in neurodevelopment and synaptic plasticity, as ...
Hurşit Ferahkaya +7 more
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Hypothalamic-Pituitary-Adrenal Axis and Epilepsy. [PDF]
J Clin NeurolEpilepsy is a recurrent, transient seizure disorder of the nervous system that affects the intellectual development, life and work, and psychological health of patients. People with epilepsy worldwide experience great suffering. Stressful stimuli such as infection, mental stress, and sleep deprivation are important triggers of epilepsy, and chronic ...
Bian X, Yang W, Lin J, Jiang B, Shao X.
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The hypothalamic-pituitary-adrenal axis and the central monoaminergic systems: a pathophysiological link to insomnia with clinical implications [PDF]
Sleep Science, 2022 The authors present a theoretical overview of the hypothalamic-pituitary-adrenal axis and the central monoaminergic systems, focusing on a putative pathophysiological relationship to insomnia complaints.
Marcio Luciano de Souza Bezerra +2 more
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Frontiers in Behavioral Neuroscience, 2021 The hypothalamic-pituitary-adrenal axis is a complex system of neuroendocrine pathways and feedback loops that function to maintain physiological homeostasis.
Julietta A. Sheng +7 more
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Thyroid and Corticosteroid Signaling in Amphibian Metamorphosis
Cells, 2022 In multicellular organisms, development is based in part on the integration of communication systems. Two neuroendocrine axes, the hypothalamic–pituitary–thyroid and the hypothalamic–pituitary–adrenal/interrenal axes, are central players in orchestrating
Bidisha Paul +4 more
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Ghrelin indirectly activates hypophysiotropic CRF neurons in rodents. [PDF]
PLoS ONE, 2012 Ghrelin is a stomach-derived hormone that regulates food intake and neuroendocrine function by acting on its receptor, GHSR (Growth Hormone Secretagogue Receptor). Recent evidence indicates that a key function of ghrelin is to signal stress to the brain.
Agustina Cabral +3 more
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The Hypothalamic‐Pituitary‐Adrenal Axis in Obesity [PDF]
Obesity Research, 1995 AbstractThe hypothalamic‐pituitary‐adrenal (HPA) axis normally maintains the concentration of Cortisol within a narrow range with a diurnal variation characterized by higher Cortisol concentrations in the morning and reduced levels in the evening. Excessive or deficient secretion of Cortisol is associated with pathologic changes.
S, Chalew, H, Nagel, S, Shore
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Nuclear Receptors as Regulators of Pituitary Corticotroph Pro-Opiomelanocortin Transcription
Cells, 2020 The hypothalamic–pituitary–adrenal (HPA) axis plays a critical role in adaptive stress responses and maintaining organism homeostasis. The pituitary corticotroph is the central player in the HPA axis and is regulated by a plethora of hormonal and stress ...
Dongyun Zhang, Anthony P. Heaney
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Urbanicity, biological stress system functioning and mental health in adolescents.
PLoS ONE, 2020 Growing up in an urban area has been associated with an increased chance of mental health problems in adults, but less is known about this association in adolescents.
Brittany E Evans +5 more
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