Results 21 to 30 of about 72,312 (262)

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

Neural Regeneration Research
The hypothalamic–pituitary–adrenal axis regulates the secretion of glucocorticoids in response to environmental challenges. In the brain, a nuclear receptor transcription factor, the glucocorticoid receptor, is an important component of the hypothalamic ...
Chonglin Su, Taiqi Huang, Meiyu Zhang, Yanyu Zhang, Yan Zeng, Xingxing Chen   +5 more
doaj   +1 more source

Psiconeuroendocrinologia do transtorno de estresse pós-traumático Psychoneuroendocrinology of posttraumatic stress disorder

Brazilian Journal of Psychiatry, 2007
OBJETIVO: Os autores realizaram uma revisão tradicional da literatura sobre os achados neurobiológicos das disfunções do eixo hipotálamo-pituitária-adrenal associados ao transtorno de estresse pós-traumático.
Juliana Elena Ruiz, Jair Barbosa Neto, Aline Ferri Schoedl, Marcelo Feijo Mello   +3 more
doaj   +1 more source

Cardiac autonomic and cortisol stress responses to real operations in surgeons: relationship with individual psychobiological characteristics and experience

BioPsychoSocial Medicine, 2023
Background Surgeons are exposed to high levels of intraoperative stress, which could compromise their psychological well-being in the long term. This study aimed at exploring the effects of real operations on the activity of stress response systems (i.e.,
Luca Carnevali, Elena Bignami, Sara Gambetta, Margherita Barbetti, Matteo Procopio, Antonio Freyrie, Paolo Carbognani, Luca Ampollini, Andrea Sgoifo   +8 more
doaj   +1 more source

Hypothalamic-pituitary-adrenal axis dysfunction induced by cancer therapy with immune checkpoint inhibitors

Сибирский онкологический журнал
Objective: to summarize current data on immune checkpoint inhibitor-induced hypothalamic-pituitary-adrenal axis dysfunction, with an emphasis on hypophysitis and primary adrenal insufficiency.Material and Methods.
A. Yu. Usynina, T. V. Saprina, N. O. Popova, E. A. Usynin, D. A. Eremin   +4 more
doaj   +1 more source

Development and Resolution of Secondary Adrenal Insufficiency after an Intra-Articular Steroid Injection

Case Reports in Endocrinology, 2022
Corticosteroid injections are commonly indicated in inflammatory conditions involving the soft tissues, tendon sheaths, bursae, and joints. Local corticosteroids carry a lower risk of complications than systemic corticosteroid but may be systemically ...
Jia Wei Tan, Sachin K. Majumdar
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Depressão e estresse: existe um endofenótipo? Depression and stress: is there an endophenotype?

Brazilian Journal of Psychiatry, 2007
OBJETIVO: Revisar os achados recentes sobre a relação entre estresse, eixo hipotálamo-pituitária-adrenal e depressão, na tentativa de explicar um endofenótipo de vulnerabilidade para o desenvolvimento da depressão.
Andrea Feijo Mello, Mario Francisco Juruena, Carmine M Pariante, Audrey R Tyrka, Lawrence H Price, Linda L Carpenter, Jose Alberto Del Porto   +6 more
doaj   +1 more source

New Onset of Fibromyalgia After Exposure to a Combat Environment: A Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Traumatic life events are hypothesized to be triggers for the onset of fibromyalgia. Posttraumatic stress disorder (PTSD) is a common comorbidity of fibromyalgia. However, limited prospective data are available on the development of fibromyalgia after exposure to high‐magnitude stress.
Jay B. Higgs, Willie J. Hale, Casey L. Straud, Jim Mintz, Stacey Young‐McCaughan, Kimberly D. Gomes, Chelsea J. Sterne, Katrina M. Lawrence‐Wolff, Alan J. Bartholomew, Kevin M. Kelly, Douglas M. Maurer, Catherine Vriend, Brett T. Litz, Douglas E. Williamson, Alan L. Peterson, for the STRONG STAR Consortium   +15 more
wiley   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source