Results 41 to 50 of about 922,924 (304)

A secretagogin locus of the mammalian hypothalamus controls stress hormone release [PDF]

, 2015
This work was supported by the Swedish Research Council (T.Ha., T.Hö.), Hjärnfonden (T.Ha.), the Petrus and Augusta Hedlunds Foundation (T.Ha., T.Hö.), the Novo Nordisk Foundation (T.Ha., T.Hö.), Karolinska Institutet (T.Hö.), the Medical University of ...
Marc Landry, Alpár, Alán, Robert Schnell, Botting, Catherine H., André Calas, Shirran, Sally Lorna, Miklós Palkovits, Fuszard, Matthew Alexander, Wagner, Ludwig, Fuszard, Matthew, Zhang, Ming-Dong, Árpád Dobolyi, Jan Mulder, Catherine H Botting, Sten Linnarsson, Tibor Harkany, Lauren Spence, Spence, Lauren, Harkany, Tibor, Sally L Shirran, Matthew Fuszard, Uhlen, Mathias, Hökfelt, Tomas, Landry, Marc, Shirran, Sally L., Martens, Henrik, Amit Zeisel, Mathias Uhlen, Romanov, Roman A., Botting, Catherine Helen, Tomas Hökfelt, Calas, André, Oláh, Márk, Alán Alpár, Harald H Sitte, Linnarsson, Sten, Márk Oláh, Henrik Martens, Roman A Romanov, Schnell, Robert, Ming‐Dong Zhang, Ludwig Wagner, Sitte, Harald H., Uhlén, Mathias,, Dobolyi, Árpád, Zeisel, Amit, Mulder, Jan, Palkovits, Miklós   +47 more
core   +1 more source

Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis. [PDF]

, 2022
Alterations in hypothalamic-pituitary-adrenal (HPA) axis and its effector hormone cortisol have been proposed as one possible mechanism linking child maltreatment experiences to health disparities.
Schmidt, Stefanie J., Schär, Selina, Koenig, Julian, Mürner-Lavanchy, Ines, Kaess, Michael   +4 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Depressão e estresse: existe um endofenótipo? Depression and stress: is there an endophenotype?

Brazilian Journal of Psychiatry, 2007
OBJETIVO: Revisar os achados recentes sobre a relação entre estresse, eixo hipotálamo-pituitária-adrenal e depressão, na tentativa de explicar um endofenótipo de vulnerabilidade para o desenvolvimento da depressão.
Andrea Feijo Mello, Mario Francisco Juruena, Carmine M Pariante, Audrey R Tyrka, Lawrence H Price, Linda L Carpenter, Jose Alberto Del Porto   +6 more
doaj   +1 more source

Impairment of adrenocortical function associated with increased plasma tumor necrosis factor-alpha and interleukin 6 concentrations in African trypanosomiasis [PDF]

, 1994
African sleeping sickness (SS) is a severe, potentially lethal parasitic disease. The treatments of choice are the antiparasitic agents suramin, which is adrenotoxic, and/or melarsoprol. We evaluated the functional integrity of the hypothalamic-pituitary-
Winkelmann, W., Reincke, M, Allolio, B., Siekmann, L., Heppner, C, Arlt, W, Petzke, F, Arlt, W., Mbulamberi, D, Vollmer, D, Chrousos, G. P., Allolio, B, Siekmann, L, Vollmer, D., Heppner, C., Mbulamberi, D., Winkelmann, W, Reincke, Martin, Petzke, F., Chrousos, G P   +19 more
core   +1 more source

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source

Impact of stress on male fertility: role of gonadotropin inhibitory hormone

Frontiers in Endocrinology
Studies have implicated oxidative stress-sensitive signaling in the pathogenesis of stress-induced male infertility. However, apart from oxidative stress, gonadotropin inhibitory hormone (GnIH) plays a major role.
Adeyemi F. Odetayo, Adeyemi F. Odetayo, Roland E. Akhigbe, Roland E. Akhigbe, Grace E. Bassey, Moses A. Hamed, Moses A. Hamed, Moses A. Hamed, Luqman A. Olayaki   +8 more
doaj   +1 more source

Multi‐Layer Transcriptomic Comparison Across Human, Pig, and Mouse Informs Tissue‐ and Trait‐Specific Animal Model Selection

Advanced Science, EarlyView.
We integrated RNA‐seq data from humans, pigs, and mice across 15 matched tissues based on 14 910 one‐to‐one orthologous genes. Cross‐species similarity was systematically evaluated across multiple regulatory layers, including global co‐expression conservation, co‐expression networks, tissue‐specific programs, and 3D genome architecture.
Jingwen Dou, Yong Liao, Xiong Shen, Xin Huang, Zhenshuang Tang, Yuwei Gou, Huajun Zhou, Jingya Xu, Hong Liu, Yue Wang, Keke Liang, Jia Liu, Xiao Zhang, Chenyao Li, Shangjian Wang, Liangliang Fu, Lilin Yin, Xinyun Li, Shuhong Zhao, Xiaolei Liu, Jingjin Li, Yuhua Fu   +21 more
wiley   +1 more source