Results 71 to 80 of about 920,236 (292)

Stress during Pregnancy and Offspring Pediatric Disease: A National Cohort Study [PDF]

, 2011
Background: Identifying risk factors for adverse health outcomes in children is important. The intrauterine environment plays a pivotal role for health and disease across life.
Tegethoff, Marion, Olsen, Jørn, Schaffner, Emmanuel, Greene, Naomi, Jørn Olsen, Meinlschmidt, Gunther, Gunther Meinlschmidt, Marion Tegethoff, Naomi Greene, Emmanuel Schaffner   +9 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Larger amygdala volumes after childhood trauma associated with depression and cortisol response to psychosocial stress in adulthood

European Journal of Psychotraumatology, 2012
Background : Childhood trauma is a major risk factor for the development of affective disorders later in life. We sought to determine whether this risk is linked to neurostructural changes in limbic brain regions after childhood trauma.
Claudia Buss, Jens C. Pruessner, Helen Mayberg, Tanja Mletzko, Charles Nemeroff, Christine Heim   +5 more
doaj   +1 more source

Early-life neighborhood context, perceived stress, and preterm birth in African American Women

SSM: Population Health, 2019
Stressors from multiple sources, across the life-course, may have independent and joint associations with preterm birth (PTB) risk in African American women. Using data from the Life-course Influences on Fetal Environments Study (LIFE; 2009–2011) of post-
Shawnita Sealy-Jefferson, Faheemah N. Mustafaa, Dawn P. Misra   +2 more
doaj   +1 more source

Neurobiology of resilience to early life stress

Neuropsychopharmacology
The early years of life are a critical period for brain development, encompassing high sensitivity to adverse experiences. Early life stress (ELS) is known to "scar" the brain and shape mental health trajectories later in life. Still, a great percentage of children faced with ELS develop adaptive competencies that maintain normal physiological and ...
Angélica Torres-Berrío, Alessandro Bortolami, Catherine J. Peña, Eric J. Nestler   +3 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Adverse effects of early-life stress: focus on the rodent neuroendocrine system

Neural Regeneration Research
Early-life stress is associated with a high prevalence of mental illnesses such as post-traumatic stress disorders, attention-deficit/hyperactivity disorder, schizophrenia, and anxiety or depressive behavior, which constitute major public health problems.
Seung Hyun Lee, Eui-Man Jung
doaj   +1 more source

Effects of Stress Early in Life on Drug Abuse at Adolescent Period in Rats [PDF]

, 2002
We have previously reported that stress early in life resulted in long-term behavioral and neurochemical alter-ations in later life. In this study, we aimed to examine the effect of stress early in life on drug abuse at adolescent period using ...
김동구
core  

Heritability of resistance to oxidative stress in early life [PDF]

Journal of Evolutionary Biology, 2010
AbstractOxidative stress has recently been suggested to play an important role in life‐history evolution, but little is known about natural variation and heritability of this physiological trait. Here, we explore phenotypic variation in resistance to oxidative stress of cross‐fostered yellow‐legged gull (Larus cachinnans) chicks.
S-Y, Kim, J C, Noguera, J, Morales, A, Velando   +3 more
openaire   +2 more sources

Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress [PDF]

, 2012
Environmentally induced epigenetic alterations are related to mental health. We investigated quantitative DNA methylation status before and after an acute psychosocial stressor in two stress-related genes: oxytocin receptor (OXTR) and brain-derived ...
Dempster, E., Dempster, Emma, Unternaehrer, Eva, Lieb, Roselind, Meyer, A. H., Unternaehrer, E., Luers, P., Mill, J., Staehli, S., Hellhammer, D. H., Meyer, Andrea H., Lieb, R., Meinlschmidt, G., Staehli, Simon, Mill, John, Hellhammer, Dirk H., Meinlschmidt, Gunther   +16 more
core   +1 more source