Results 71 to 80 of about 4,035,262 (238)
Down-regulation of hypothalamic corticotropin-releasing hormone messenger ribonucleic acid (mRNA) precedes early-life experience-induced changes in hippocampal glucocorticoid receptor mRNA. [PDF]
, 2001 Early-life experiences, including maternal interaction, profoundly influence hormonal stress responses during adulthood. In rats, daily handling during a critical neonatal period leads to a significant and permanent modulation of key molecules that ...
Avishai-Eliner, S +4 more
core +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance This longitudinal study demonstrates within-individual pubertal recalibration of the HPA axis in humans. Findings provide empirical support for an adolescent window of plasticity during which the brain resamples the environment and alters ...
M. Gunnar +4 more
semanticscholar +1 more source
Telomeres, Early-Life Stress and Mental Illness [PDF]
, 2015 Telomeres are structures of tandem TTAGGG repeats that are found at the ends of chromosomes and preserve genomic DNA by serving as a disposable buffer to protect DNA termini during chromosome replication. In this process, the telomere itself shortens with each cell division and can consequently be thought of as a cellular 'clock', reflecting the age of
Samuel J, Ridout +6 more
openaire +2 more sources
Early life stress as an influence on limbic epilepsy: an hypothesis whose time has come?
Frontiers in Behavioral Neuroscience, 2009 The pathogenesis of mesial temporal lobe epilepsy (MTLE), the most prevalent form of refractory focal epilepsy in adults, is thought to begin in early life, even though seizures may not commence until adolescence or adulthood.
Amelia S Koe +2 more
doaj +1 more source
Developmental stress and social phenotypes : integrating neuroendocrine, behavioural and evolutionary perspectives [PDF]
, 2017 The social world is filled with different types of interactions, and social experience interacts with stress on several different levels. Activation of the neuroendocrine axis that regulates the response to stress can have consequences for innumerable ...
Spencer, Karen A.
core +1 more source
Neuropsychiatric Disease and Treatment, 2008 Robert Paul1, Lorrie Henry2, Stuart M Grieve3, Thomas J Guilmette2,4, Raymond Niaura4, Richard Bryant5, Steven Bruce1, Leanne M Williams3,6, Clark C Richard7, Ronald A Cohen4, Evian Gordon3,71University of Missouri, St. Louis, St.
Robert Paul +5 more
doaj
Altered hypothalamic DNA methylation and stress-induced hyperactivity following early life stress
Epigenetics & Chromatin, 2021 Exposure to early life stress (ELS) during childhood or prenatally increases the risk of future psychiatric disorders. The effect of stress exposure during the neonatal period is less well understood.
Eamon Fitzgerald +6 more
doaj +1 more source
Transgenerational transmission of a stress-coping phenotype programmed by early-life stress in the Japanese quail [PDF]
, 2017 This study was funded by a BBSRC David Phillips Research Fellowship to K.A. Spencer (BB/L002264/1).An interesting aspect of developmental programming is the existence of transgenerational effects that influence offspring characteristics and performance ...
Boogert, Neeltje J +3 more
core +2 more sources
Stress, 2019 Childhood maltreatment and neglect lead to a wide range of mental disorders highlighted by hormone and immune alterations in neglected children. This social-health challenge has led to the creation of early stress models such as maternal separation (MS ...
María Banqueri +3 more
semanticscholar +1 more source
Noradrenergic alterations associated with early life stress
Neuroscience & Biobehavioral ReviewsSignificant stress in childhood or adolescence is linked to both structural and functional changes in the brain in human and analogous animal models. In addition, neuromodulators, such as noradrenaline (NA), show life-long alterations in response to these early life stressors, which may impact upon the sensitivity and time course of key adrenergic ...
Megan Sheppard +5 more
openaire +2 more sources