Results 51 to 60 of about 541,912 (259)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Loading protocols in dental implantology: A narrative review
SRM Journal of Research in Dental SciencesIntroduction: Dental implant success depends significantly on loading protocols, with immediate loading gaining popularity due to patient demands for faster, esthetic results.
Deepesh Saxena +2 more
doaj +1 more source
Strut and Tie Modelling of Reinforced Concrete Deep Beams Under Static and Fixed Pulsating Loading
مجلة النهرين للعلوم الهندسية, 2020 Numerical analysis of the performance of reinforced concrete (RC) deep beam subjected to static and fixed-point pulsating loading at the midpoint has been investigated. Three-dimensional nonlinear finite element model using the Strut and Tie approach was
Ajibola Ibrahim Quadri
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Health Science ReportsBackground and Aims Edentulous patients often receive mandibular overdentures retained by dental implants; however, the optimal loading protocol (immediate/early vs. delayed loading) for minimizing marginal bone loss (MBL) remains uncertain.
Morteza Sharifi +6 more
doaj +1 more source
Influence of Nanotopography on Early Bone Healing during Controlled Implant Loading
Nanomaterials, 2020 Nanoscale surface modifications influence peri-implant cell fate decisions and implant loading generates local tissue deformation, both of which will invariably impact bone healing.
Renan de Barros e Lima Bueno +5 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Effect of curing temperatures on the early-age tensile creep behavior of high-performance concrete
Case Studies in Construction MaterialsHigh-performance concrete (HPC) is prone to cracking due to significant early autogenous shrinkage. Tensile creep (TC) can effectively relieve stress restraint and mitigate crack propagation.
Yuanxi Wang +5 more
doaj +1 more source
Strong family history and early onset of schizophrenia: about 2 families in Northern Nigeria
The Pan African Medical Journal, 2016 Schizophrenia is a highly heritable psychotic disorder and high genetic loading is associated with early onset of the disease. The outcome of schizophrenia has also been linked with the age of onset as well as the presence of family history of the ...
Folorunsho Tajudeen Nuhu +3 more
doaj +1 more source