Results 91 to 100 of about 4,392 (296)

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and early maladaptive schemas: A single case study.

, 2018
Background/Aims: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex illness, one that is devastating and life changing for many people.
Stalmeisters, Dzintra
core  

Epidemiological Signals, Knowledge Gaps, and Practice Considerations From the 2024 Functional Neurological Disorder Society International Meeting: A Conference Report With Narrative Synthesis

Medicine Bulletin, EarlyView.
ABSTRACT The 2024 International Conference on Functional Neurological Disorders brought together clinicians, researchers, advocates, and service‐user representatives to discuss recent developments in functional neurological disorder and related functional disorders.
Yadira Velazquez‐Rodriquez, Jennifer Brown, Katherine Gill   +2 more
wiley   +1 more source

The Comparison of Maladaptive Schema and Lifestyles in Drug Dependence and Non-Drug Dependence People

Research on Addiction, 2013
Objective: The aim of this study was to compare early maladaptive schemas and life styles in drug dependences and normal population to recognize their role in drug dependence.
Vahideh Purmohammad, Hasan Yaghoubi, Rahim Yousefi, Ali Mohammadzadeh, Mahmod Najafi   +4 more
doaj  

Conditional Modeling of GNAO1 Disorder Dissociates Circuit Specific Contributions to Pathology and Rationalizes Ameliorative Strategies

Movement Disorders, EarlyView.
Abstract Background Neurodevelopmental disorders feature various symptoms that frequently include seizures and motor manifestations, but their attribution to disruptions of specific circuits and molecular alterations is notoriously hard to establish, which limits therapeutic interventions.
Gloria Brunori, Stefano Zucca, Colten K. Lankford, Yi‐Zhi Wang, Marianna Franco, Nina A. Alekseeva, Sevinj Ahmedova, Han My Van, Jeffrey N. Savas, Kirill A. Martemyanov   +9 more
wiley   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, EarlyView.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

Using a social‐ecological macrosystems framework to understand how human activities alter ecological synchrony

People and Nature, EarlyView.
Abstract Different aspects of ecological systems, biotic or abiotic, often fluctuate in coordinated patterns over space and time. Such high concordance between ecological processes is often referred to as ecological synchrony. Human activities, including and beyond climate change, have the potential to alter ecological synchrony by disrupting or ...
Yiluan Song, Mallory Barnes, K. Ann Bybee‐Finley, Kyla M. Dahlin, Travis McDevitt‐Galles, Stephan B. Munch, Guillermo E. Ponce‐Campos, Casey Youngflesh, Benjamin Zuckerberg, Kai Zhu   +9 more
wiley   +1 more source

Life satisfaction prediction based on early maladaptive schemas and lifestyle in nurses

مجله علوم روانشناختی, 2020
Background: Numerous studies have predicted life satisfaction, but life satisfaction prediction based on early maladaptive schemas and lifestyles has been neglected.
Hossein Ilanloo, Sedigheh Ahmadi, Nastaran Farahani, Mohammad Bagher Hasani, Manoochehr Rezaei   +4 more
doaj  

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Speciation with gene flow

PLANTS, PEOPLE, PLANET, EarlyView.
Biodiversity is threatened by human activities, with extinction debt accumulating rapidly. Many of these activities change the connectivity of populations, fragmenting existing population systems or bringing previously isolated populations or species into contact.
Zhiqin Long, Xu Zhang, Yue Yu, Gregory L. Owens, Diana J. Rennison, Clarisse Palma‐Silva, Daniel Ortiz‐Barrientos, Loren H. Rieseberg   +7 more
wiley   +1 more source