Results 71 to 80 of about 4,774,290 (284)

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source

A Comparison of Early Maladaptive Schemas in Crystal Addicted Individuals and Normal Individuals

Research on Addiction, 2011
Objective: The aim of present research was to compare early maladaptive schemas in crystal addicted individuals and normal individuals. Method: In this ex post facto research, two groups of subjects (normal adolescent=30 and addicted adolescent=30) were ...
Zahra Asadi, Sara Amiri, Aryan Pourkamali   +2 more
doaj  

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Predicting Inefficient Problem-Solving Methods based on Early Maladaptive Schemas in Drug-Dependent Individuals [PDF]

Research on Addiction, 2021
Objective: The aim of this study was to predict the inefficient problem-solving methods of drug-dependent individuals based on early maladaptive schemas. Method: This study was a descriptive-correlational research. The statistical population of the study
Mohammad Hosein Sharifinia, zahra Rahimi yeganeh, Mohammad Rahimi dastjerdi   +2 more
doaj  

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source

The Effect of Schema Therapy on Anxiety, Depression, and Early Maladaptive Schemas in Individuals with Substance Use Disorder [PDF]

Research on Addiction, 2021
Objective: The aim of this study was to determine the effect of schema therapy on depression, anxiety, and early maladaptive schemas in individuals with substance use disorder.
hossein mohagheghi, parviz kharghani
doaj  

Tau Aggregate Imaging and Transcriptomics of Alzheimer's Disease Brain at Different Stages of Disease

Advanced Science, EarlyView.
The protein aggregates and gene expression in the middle temporal gyrus (MTG) and somatosensory cortex (SOM) of the postmortem brains of 13 Alzheimer's disease patients were studied in detail, revealing that small hyperphosphorylated tau aggregates increase with Braak stage driven by microglial inflammation.
Elizabeth A. English, Dorothea Böken, Matthew W. Cotton, Matthew R. Cheetham, Johanna S. Jackson, Georg Meisl, John S. H. Danial, Paul M. Matthews, Nurun N. Fancy, David Klenerman   +9 more
wiley   +1 more source

Predicting Bullying and Antisocial Behaviors Based on Early Maladaptive Schemas and Defense Mechanisms in Drug Abusers [PDF]

Research on Addiction, 2022
Objective: The aim of this study was to investigate the relationship between bullying and antisocial behaviors with early maladaptive schemas and defense mechanisms among drug addicts. Method: The research method was descriptive-correlation.
saeed shalchi, Ali mohammadzadeh, Nahid Yousefpour   +2 more
doaj  

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source