Results 71 to 80 of about 30,157 (379)

Early Maladjustment Schemas in Individuals with and without Type 2 Diabetes Mellitus [PDF]

, 2019
Objective. This study explored Early Maladjustment Schemas (EMSs) among individuals with and without type 2 diabetes mellitus and examined potential moderating roles for gender, level of education, and occupation. Methods.
Gholamrezaei, Simin, Khodarahimi, Siamak, Mirdrikvand, Fazlolah, Rahimian Bougar, Mojtaba, Sepahvandi, Mohamad Ali, Shafikhani, Pejman   +5 more
core   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Comparing early maladaptive schemas and defense mechanisms with religious attitude: A case of obsessive-compulsive disorder

پژوهش در دین و سلامت, 2017
For downloading the full-text of this article please click here. Background and Objective: Obsessive-compulsive disorder (OCD) is one of the most challenging clinical issues.
Hengameh Bolorsaz Mashhadi, Mehdi Nasiry Poor, Mehdi Malvirani, Azita Amir Fakhraei   +3 more
doaj  

The relationship between early maladaptive schemas and attitude to meta -marriage relationships with mediating dimensions of mindfulness in order to present the model

مجله علوم روانشناختی, 2020
Background: Early maladaptive schemas are factors that can affect the lives and relationships between couples. But the key question is, can the dimensions of mindfulness mediate the relationship between early maladaptive schemas and attitudes toward ...
fatemeh mahdyzadeh, ali darekordi
doaj  

The relationship between disordered eating behavior with early maladaptive schemas and anxiety in adolescent female [PDF]

Ravānshināsī-i Afrād-i Istis̠nāyī, 2017
Aim: The current research aim is studying the relationship between disordered eating behavior (DEB) with early maladaptive schemas(EMS) and anxiety in adolescent female students in Shiraz .Method: The method of present research is descriptive correlation.
manijej kaveh, Fariba Tabe Bordbar
doaj   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

On the Prediction of Opium Addicts’ Changeability through Early Maladaptive Schemas and Attachment Styles

Research on Addiction, 2016
Objective: This study was an attempt to investigate the role of early maladaptive schemas and attachment styles in changeability of opium addicts. Method: The research method was descriptive-correlation and the number of 162 male opium addicts was ...
F Asghari, G Alipour, A Saeadi
doaj  

PTSD from Childhood Trauma as a Precursor to Attachment Issues [PDF]

, 2016
The past 20 years have been turbulent regarding Reactive Attachment Disorder (RAD), with conflicting research about its causes, effects, treatment, and prognosis. The current diagnostic criteria in the DSM-5 fails to adequately address this disorder.
Owen, Christy
core   +1 more source

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source