Results 81 to 90 of about 30,157 (379)

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

open access: yesAdvanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li   +11 more
wiley   +1 more source

Anger and assaultiveness of male forensic patients with developmental disabilities : links to volatile parents [PDF]

open access: yes, 2008
This study with 107 male forensic patients with developmental disabilities investigated whether exposure to parental anger and aggression was related to anger and assaultiveness in a hospital, controlling for background variables.
Novaco, Raymond, Taylor, John
core   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

open access: yesAdvanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li   +14 more
wiley   +1 more source

Investigation of the relationship between early maladaptive schemas, temperament and eating attitude in adults

open access: yesJournal of Eating Disorders, 2022
Plain English Summary This study examined the relationship between early maladaptive schemas, temperament, eating attitude and the effect of gender variable on these concepts in adults.
Kahraman Güler, Zeynep Özgörüş
doaj   +1 more source

Cognitive-Behavioral Therapy [PDF]

open access: yes, 2015
Cognitive-behavioral therapy (CBT) is the merging of behavioral and cognitive therapies that mostly focuses on working with the client in the present. Although there are many approaches to CBT, there tend to be some common features.
Rice, Robert H.
core   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

open access: yesAdvanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia   +13 more
wiley   +1 more source

The mediating role of early maladaptive schemas on the relationship between attachment styles and defense mechanisms

open access: yesمجله علوم روانشناختی, 2019
Background: Attachment styles, early maladaptive schemas and defense mechanisms are the major determinants of psychological problems. Discovering the relationships of these variables has theoretical and clinical importance.
Mohammad Ali Besharat   +2 more
doaj  

Relations between God-Images and Early Maladaptive Schemas.

open access: yesPsychiatria Danubina, 2021
Our God image not only determines the nature of our relationship with God, it also influences our personality, actions, self-concept, mindset and social relations. It acts within and through us. Although everyone has a God image - regardless of whether one is a believer or not - the ways in which we experience God's relation to us are manifold.
Ferenczi, Andrea   +2 more
openaire   +2 more sources

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

open access: yesAdvanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang   +10 more
wiley   +1 more source

A Comparison of Early Maladaptive Schemas in Crystal Addicted Individuals and Normal Individuals

open access: yesResearch on Addiction, 2011
Objective: The aim of present research was to compare early maladaptive schemas in crystal addicted individuals and normal individuals. Method: In this ex post facto research, two groups of subjects (normal adolescent=30 and addicted adolescent=30) were ...
Zahra Asadi   +2 more
doaj  

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