Results 141 to 150 of about 1,357,390 (361)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Crowd in the Early Middle Ages. By ShaneBobrycki. Princeton and Oxford: Princeton University Press. 2024. xxi + 313 pp. £35/$39.95. ISBN 9780691189697. [PDF]

Edward Roberts
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

An Agglomeration of Early Middle Ages: Meda'in

, 2014
The group of the cities of Meda'in, the administrative capital of the Sassanid Empire from the early Middle Ages to the collapse of this empire, is one of the biggest metropolises of the antiquity and of the Middle Ages. The group of the cities of Meda'in, consisting of many cities and towns built in different sizes and various times, has a diverse ...
Bakir, Abdulhalik, Altungök, Ahmet
openaire   +2 more sources

Соціально-правові засади управління трудовими ресурсами тюркських держав раннього cередньовіччя [PDF]

У статті досліджуються процеси державотворення у тюрків періоду раннього Середньовіччя. Вивчаються проблеми економічного забезпечення державотворчих процесів.
Сацький, Павло Вікторович
core   +1 more source

Biostratigraphie par Acritarches du Cambro-Ordovicien de Belgique et des regions limitotrophes: synthese et perspectives d'avenir [PDF]

, 1992
The stratigraphic significance of Cambrian and Ordovician acritarchs in Belgium and adjacent areas is discussed. It now appears that the age of the Deville group in the Ardenne (more precisely the upper part of this group) should be broadened to include ...
Vanguestaine, M.
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Experimental Analysis of Metal Points from Quattro Macine: Reproduction and Interpretation

EXARC Journal, 2019
This paper relates to a study of experimental archaeology, executed by Ruben Cataldo, about the forging methods used to produce some replicas of two metal points found during the archaeological excavations carried out between 1992 and 1996 by the ...
Ruben Cataldo
doaj  

Justitia verbeeld, gerechtigheid gekaderd: recht in de kunst [PDF]

, 2011
General introduction to 'Law and Iconography'. How are 'law' and 'justice' represented in the middle ages and early modern times? Painted exempla iustitiae in court rooms, the history of Lady Justice and the respresentation of the legal ...
Martyn, Georges
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source