Results 51 to 60 of about 299,641 (309)

“Hegemonia” e “Intelectual Orgânico” na Primeira Idade Média: Gregório I e a (re)elaboração do vocábulo-conceito de rector

História
Resumo Este artigo pretende analisar Gregório I (540-604) como intelectual orgânico do papado frente às monarquias germânicas, isto é, traçar as estratégias do bispo de Roma para firmar sua posição como facção hegemônica frente aos Estados ampliados ...
João Paulo Charrone
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

State and society in the early Middle Ages: the Middle Rhine Valley, 400–1000

, 2006
Book synopsis: This book shows just how much can be discovered about the so-called "Dark Ages," between the fall of Rome and the high Middle Ages. Whereas it is believed widely that the source materials for early medieval Europe are too sparse to allow ...
Innes, Matthew
core  

Changes in Scale in the Italian Countryside from Late Antiquity to the Early Middle Ages

, 2011
Even if in Italy there is a tendence to emphasize a continuity between the Late Antique era and the Early Medieval Ages, we cannot deny that a radical break took place (on a quantitative as well as a qualitative scale) between the 5th and the 7th ...
CHAVARRIA ARNAU, ALEJANDRA, Alexandra Chavarría Arnau   +1 more
core   +1 more source

Nie wszystko „tarło” co ma zęby – w poszukiwaniu funkcji

Slavia Antiqua, 2016
This article presents the research related to identifying the actual function of an object made of deer bones excavated in Kujawy, in the village of Brzezie (site 4).
Kamilla Waszczuk, Daniel Żychliński, Piotr Pachulski, Robert Prawniczak   +3 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Cremation in the Early Middle Ages: Death, fire and identity in North-West Europe [PDF]

Introducing this first-ever edited collection drawing together the latest research on the cremation of the dead in early medieval North-West Europe, the chapter identifies, rationalises and contextualises the book’s aims: to rethink the burning of the ...
Lippok, Femke, Williams, Howard
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Hominin footprints from Early Pleistocene deposits at Happisburgh, UK [PDF]

, 2014
The research was funded by the Calleva Foundation as part of the Pathways to Ancient Britain Project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Investigations at ...
Simon A. Parfitt, Hoare, Peter, Chris Stringer (67811), Williams Craig, Duffy, Sarah M., Simon A Parfitt, Lewis, M, Duffy, Sarah M, Peter Hoare, Peter Hoare (582679), De Groote, I, Parfitt, SA, Williams, Craig, Bates, M, Sarah M Duffy, Bates, R, Parfitt, Simon A, Isabelle De Groote, Martin Bates, Sarah M. Duffy (582676), Peglar, S, Duffy, SM, Ashton, N, Bates, Martin, Richard Bates (582678), Lewis, SG, Martin Bates (582677), Simon G Lewis, Chris Stringer, Lewis, Simon G, Parfitt, Simon A., Peglar, Sylvia, Isabelle De Groote (582675), Hoare Peter, Bates Richard, Williams, C, Sarah M. Duffy, Simon G. Lewis (582674), Simon G. Lewis, Stringer, C, Ashton, Nick, Mark Lewis, De Groote Isabelle, Duffy Sarah M., Hoare, P, Sylvia Peglar (582680), Craig Williams (582681), Ashton Nick, Sylvia Peglar, Stringer Chris, Stringer, Chris, Nick Ashton, Simon A. Parfitt (229984), Bates Martin, Bates, Richard, Bates, C. Richard, De Groote, Isabelle, Lewis Mark, Richard Bates, Parfitt Simon A., Nick Ashton (388306), Mark Lewis (393467), Lewis, Mark, Lewis, Simon G., Lewis Simon G., Peglar Sylvia, Craig Williams   +66 more
core   +1 more source