Results 61 to 70 of about 299,641 (309)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Presenting Medieval Gambling and Pub Life
EXARC Journal, 2012 There are many legendary games in the Middle Ages with professed losses of clothes, horses and, what is more, whole estates, and even halves of kingdoms. But was money really the most important part of gambling?
Zsuzsanna Sőregi
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2011 [Extract] The Middle Ages have proved to be imaginatively a fluid and artistically enticing entity. As Umberto Eco has underscored, many have turned to the Middle Ages for inspiration and diverse forms of confirmation (66-72).
Ackland, Michael
core
Ancestry and kinship in a Late Antiquity-Early Middle Ages cemetery in the Eastern Italian Alps. [PDF]
iScience, 2023 Coia V +6 more
europepmc +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Christendom and christianity in the middle ages
, 1993 Though buffetted on all sides by rapid and at times cataclysmic social, political, and economic change, the medieval church was able to make adjustments that kept it from becoming simply a fossil from the past rather than an enduring institution of ...
Bruinsma, Reinder, Bredero, Adriaan H.
core
Ранносредновековно селище до с. Драговищица, община Kостинброд
Приноси към българската археология, 2018 The article presents the results of the rescue archaeological excavations carried out at the medieval settlement found at site N 5. The settlement is situated to the south of the village of Dragovishtitsa, Kostinbrod municipality (Fig. 1).
Valeri Grigorov
doaj
La mission archéologique de Jebel Oust, site antique de Tunisie
Archéopages, 2010 The Tunisian site of Jebel Oust (beginnings of the Empire to early 7th c.) is a place of worship (temple) associated with a hot spring (thermae and tanks).
Raphaël Durost +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source